Influence of genotypes at SAA1 and SAA2 loci on the development and the length of latent period of secondary AA-amyloidosis in patients with rheumatoid arthritis
Influence of genotypes at SAA1 and SAA2 loci on the development and the length of latent period of secondary AA-amyloidosis in patients with rheumatoid arthritis
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SAA1和SAA2位点基因型对类风湿性关节炎患者继发性AA淀粉样变性发生及潜伏期长度的影响
DOI：
10.1007/s004399900150
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发表时间：
1999
期刊：
影响因子：
5.3
通讯作者：
Ching
中科院分区：
文献类型：
--
作者：
M. Moriguchi;C. Terai;Y. Koseki;M. Uesato;A. Nakajima;S. Inada;M. Nishinarita;S. Uchida;A. Nakajima;Seong;Ching
为了研究SAA基因座的多态性是否与淀粉样蛋白A（AA）-淀粉样变性的发生相关，我们确定了43例AA-淀粉样变性患者（淀粉样变性人群）和77例患病时间少于5年的类风湿性关节炎（RA）患者（早期RA人群）的SAA 1和SAA 2基因座的基因型。我们还比较了90名韩国人，95名台湾人和103名日本健康受试者中SAA 1基因座的基因型频率。SAA 1位点γ/γ基因型和γ等位基因频率在淀粉样变组显著高于早期RA组（34.9%vs7.8%，58.1%vs33.8%，χ2检验P=0.0001）。在韩国人、台湾人和日本人中，SAA 1位点的γ等位基因频率分别为41.6%、35.6%和37.4%。SAA 1位点γ等位基因数目少的AA型淀粉样变潜伏期明显延长（斯皮尔曼相关系数为-0.42，P <0.05）。另一方面，SAA 1位点γ等位基因数目较多的患者在诊断为AA淀粉样变性前2年内的平均C反应蛋白（CRP）水平显著较高（斯皮尔曼相关系数：0.34，P<0.05）。淀粉样变性与SAA 2基因多态性之间无显著关联。我们推测等位基因SAA 1 γ可能通过影响RA炎症的严重程度而使RA患者易患淀粉样变性。
To examine whether polymorphism at the SAA loci is associated with the development of amyloid protein A (AA)-amyloidosis, we determined the genotypes at the SAA1 and SAA2 loci in 43 AA-amyloidosis patients (amyloidosis population) and 77 patients with rheumatoid arthritis (RA) who had been ill for less than 5 years (early RA population). We also compared the frequencies of the genotypes at the SAA1 locus among 90 Korean, 95 Taiwanese, and 103 Japanese healthy subjects. The frequencies of the γ/γ genotype and γ alleles at the SAA1 locus were significantly higher in the amyloidosis population than in the early RA population (34.9% versus 7.8%, and 58.1% versus 33.8%, χ2 test P=0.0001). The frequencies of the γ allele at the SAA1 locus in Koreans, Taiwanese, and Japanese were 41.6%, 35.6%, and 37.4%, respectively. The length of the latent period of AA-amyloidosis was significantly longer in the patients with smaller numbers of the γ allele at the SAA1 locus (Spearman's correlation coefficient: –0.42, P<0.05). On the other hand, the mean C-reactive protein (CRP) level during 2 years prior to the diagnosis of AA-amyloidosis was significantly higher in the patients with larger numbers of the γ allele at the SAA1 locus (Spearman's correlation coefficient: 0.34, P<0.05). No significant association was found between amyloidosis and polymorphism at the SAA2 locus. We postulate that the allele SAA1 γ renders an RA patient susceptible to amyloidosis, possibly by affecting the severity of inflammation in RA.
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影响因子：
2.9
作者：
PRELLI, F;PRAS, M;FRANGIONE, B
通讯作者：
FRANGIONE, B
DOI：
10.1016/0925-4439(94)00076-3
发表时间：
1995-01-25
影响因子：
6.2
作者：
LIEPNIEKS, JJ;KLUVEBECKERMAN, B;BENSON, MD
通讯作者：
BENSON, MD
影响因子：
15.9
作者：
KLUVEBECKERMAN, B;DWULET, FE;BENSON, MD
通讯作者：
BENSON, MD
淀粉样蛋白增强负载因子巨噬细胞在淀粉样蛋白纤维形成中的作用。
DOI：
--
发表时间：
1990
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Shirahama,T;Miura,K;Ju,ST;Kisilevsky,R;Gruys,E;Cohen,AS
通讯作者：
Cohen,AS
来自单个个体的多种形式的淀粉样蛋白相关血清蛋白 SAA 的氨基酸结构。
影响因子：
2.9
作者：
Dwulet,FE;Wallace,DK;Benson,MD
通讯作者：
Benson,MD