E-cigarette Use and Disease Outcomes in Inflammatory Bowel Diseases: A Case-Control Study.
E-cigarette Use and Disease Outcomes in Inflammatory Bowel Diseases: A Case-Control Study.
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电子烟的使用和炎症性肠病的疾病结果：病例对照研究。
DOI：
10.1007/s10620-022-07539-z
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发表时间：
2023
影响因子：
3.1
通讯作者：
Ananthakrishnan,AshwinN
中科院分区：
文献类型：
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作者：
Sheehan,GabrielT;Twardus,ShainaW;Cagan,Andrew;Ananthakrishnan,AshwinN
传统香烟的使用对克罗恩病（CD）的疾病结局有不利影响。在过去的十年中，电子烟的使用在全球范围内有所增加。使用含尼古丁的电子烟对CD或溃疡性结肠炎（UC）的疾病结局的影响尚未得到很好的定义。MethodsThis是一项回顾性病例对照研究，研究对象是CD或UC患者，他们目前使用含尼古丁的电子烟（病例）。每个病例与两个非vaping对照组相匹配。我们的主要研究结果是2年内新生物制剂的开始、现有生物制剂治疗的转换或IBD相关住院或手术的复合结果。调整相关协变量的多变量模型的construction.ResultsThe研究包括127例IBD患者谁是目前的电子烟用户相比，251对照。目前的电子烟使用者比非使用者更年轻，并且更有可能以前接受过IBD相关手术。在CD患者的多变量分析中，目前使用电子烟与研究结果的高风险无关（OR 0.82，95% CI 0.36-1.87）。在目前或以前吸烟的人中没有单独观察到差异。同样，在UC患者中，目前使用电子烟与主要结局无关（OR 1.05，95%CI 0.33-3.39）。然而，需要进行更大规模的研究，特别是对从头开始使用vaping的患者进行研究，以得出可靠的结论。应劝阻患者开始使用电子烟，以认识到对整体健康的不利影响。
IntroductionTraditional cigarette use adversely impacts disease outcomes in Crohn’s disease (CD). There has been a worldwide increase in the use of e-cigarettes over the past decade. The impact of use of nicotine containing e-cigarettes on disease outcomes in CD or ulcerative colitis (UC) has not been well defined.MethodsThis was a retrospective case-control study of patients with CD or UC who were current users of nicotine containing e-cigarettes (cases). Each case was matched to two non-vaping controls. Our primary study outcome was a composite of new biologic initiation, switch of existing biologic therapy, or IBD-related hospitalization or surgery over 2 years. Multivariable models adjusting for relevant covariates were construction.ResultsThe study consisted of 127 patients with IBD who were current e-cigarette users compared to 251 controls. Current e-cigarette users were younger than non-users and were more likely to have had an IBD-related surgery previously. On multivariable analysis among those with CD, current e-cigarette use was not associated with higher risk of study outcome (OR 0.82, 95% CI 0.36–1.87). No difference was observed separately among those who were current or former smokers. Similarly, in those with UC, current e-cigarette use was not associated with the primary outcome (OR 1.05, 95% CI 0.33–3.39).ConclusionCurrent e-cigarette use was not associated with worse outcomes among patients with IBD. However, larger studies particularly of patients de novo initiating vaping are needed to draw robust conclusions. Patients should be discouraged from initiating vaping recognizing overall adverse health effects.