Near-infrared imaging of the effects of glucose ingestion and regulation on prefrontal activation during dual-task execution in healthy fasting older adults
Near-infrared imaging of the effects of glucose ingestion and regulation on prefrontal activation during dual-task execution in healthy fasting older adults
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DOI：
10.1016/j.bbr.2012.03.039
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发表时间：
2012-06-15
影响因子：
2.7
通讯作者：
Bherer, Louis
中科院分区：
文献类型：
--
作者：
Gagnon, Christine;Desjardins-Crepeau, Laurence;Bherer, Louis
基本原理：在老年人中，葡萄糖增强效应主要是在情景记忆中观察到的，但最近发现的是注意力控制表现。然而，这些影响的大脑激活模式仍然是unknowed.Objective：本研究探讨了急性影响葡萄糖摄入对前额叶脑激活过程中执行的一个分开的注意力任务在空腹非糖尿病老年adults.Methods：20老年人（60岁及以上）参加了这项研究，包括两个实验会话。在一夜禁食后，参与者接受葡萄糖饮料（50克）或安慰剂（糖精）饮料，然后他们完成了双重任务。在任务执行过程中，前额叶激活记录功能近红外光谱（fNIRS）。采用重复测量设计，使每个参与者作为他或她自己的控制。这两个实验会话被抵消的参与者之间，并进行了两个weeks apart.Results：当参与者在葡萄糖条件下，他们表现出类似的双任务成本为两个任务，而在安慰剂条件下，他们优先于其他一个任务，与一个显着更大的双任务成本为非优先任务（p < 0.01）。在右腹外侧前额叶区也观察到氧合血红蛋白和脱氧血红蛋白的不同脑激活，在葡萄糖条件下更明显激活（p < 0.05）。此外，行为和激活数据的个体差异的影响，在葡萄糖regulation.Conclusions：葡萄糖摄入似乎暂时提高空腹老年人的能力，更平等地协调两个并发任务，这是反映在大脑激活模式。(C)2012爱思唯尔有限公司版权所有。
Rationale: Glucose enhancing effects in older adults have mostly been observed for episodic memory, but have recently been found for attentional control performance. Yet, brain activation patterns underlying these effects are still unknown.Objective: The present study examined the acute effects of glucose ingestion on prefrontal brain activation during the execution of a divided attention task in fasting non-diabetic older adults.Methods: Twenty older adults (60 years and older) took part in the study that included two experimental sessions. After an overnight fast, participants received either a glucose drink (50 g) or a placebo (saccharin) drink, following which they completed a dual-task. During task execution, prefrontal activation was recorded with functional near-infrared spectroscopy (fNIRS). A repeated-measures design was used such that each participant served as his or her own control. The two experimental sessions were counterbalanced among participants and were performed two weeks apart.Results: When participants were in the glucose condition, they showed similar dual-task costs for both tasks, whereas in the placebo condition they prioritized one task over the other, with a significantly larger dual-task cost for the non-prioritized task (p < 0.01). Differential brain activation was also observed in right ventral-lateral prefrontal regions for oxygenated hemoglobin and deoxygenated hemoglobin, with more activation apparent in the glucose condition (p < 0.05). Furthermore, behavioral and activation data were influenced by individual differences in glucose regulation.Conclusions: Glucose ingestion appears to momentarily enhance fasting seniors' capacity to coordinate more equally two concurrent tasks and this is reflected in brain activation patterns. (C) 2012 Elsevier B.V. All rights reserved.