Adrenal hormonal indices of stress in laboratory rats
Adrenal hormonal indices of stress in laboratory rats
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实验大鼠应激肾上腺激素指数
DOI：
10.1016/0031-9384(87)90408-2
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发表时间：
1987
影响因子：
2.9
通讯作者：
J. Ottenweller
中科院分区：
文献类型：
--
作者：
B. Natelson;D. Creighton;R. Mccarty;W. Tapp;D. Pitman;J. Ottenweller
当个别大鼠暴露于不同强度的应激，足电击，血浆中的儿茶酚胺被认为是敏感和可靠的指标的压力。血浆皮质酮表现不佳。同样，血浆肾上腺素和去甲肾上腺素水平与应激程度的行为测量高度显著相关，即在30秒电击期间观察到的笼内运动量。重要的是，这种行为测量是敏感和可靠的压力指标，如儿茶酚胺。然而，使用的儿茶酚胺或这种行为的措施作为一个临床上有用的措施的压力水平是有限的事实，他们的反应是非常短暂的压力。尽管如此，由于儿茶酚胺能可靠而敏感地追踪压力源的强度，它们似乎是一种很好的内脏压力测量方法，也许是目前最好的方法。但是，压力的行为伴随物是快速而容易量化的，并且存在广泛的研究范围，从警觉开始，通过更唤起的运动活动的进展，并以战斗-逃跑结束。由于压力的行为伴随物没有像内分泌伴随物那样被深入研究，我们相信，未来寻找临床上有用的压力指数的努力将得到回报，即注意力从内脏反应转向明显的行为反应。
When individual rats were exposed to different intensities of a stressor, foot shock, plasma catecholamines were found to be sensitive and reliable indices of the stress. Plasma corticosterone did not perform as well. Similarly, levels of both plasma epinephrine and norepinephrine correlated highly significantly with a behavioral measure of the degree of stress—namely, the amount of movement about the cage seen during the 30 sec shock period. Importantly, this behavioral measure was as sensitive and reliable an index of stress as the catecholamines. However, use of either the catecholamines or this behavioral measure as a clinically useful measure of the level of stress was limited by the fact that their responses to the stressor were extremely short-lived. Nonetheless, because the catecholamines reliably and sensitively track the intensity of a stressor, they appear to be a good visceral measure of stress, perhaps the best currently available. But the behavioral concomitants of stress are quickly and easily quantifiable and present a wide range to study, starting with alerting, through a progression of more aroused motor activity, and ending with fight-flight. Because the behavioral concomitants of stress have not been as intensively studied as the endocrine ones, we believe that future efforts to find a clinically useful index of stress will be rewarded by a refocussing of attention away from the visceral respondent to the overt behavioral one.