Neural mediation of food aversions and anorexia induced by tumor necrosis factor and tumors
Neural mediation of food aversions and anorexia induced by tumor necrosis factor and tumors
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DOI：
10.1016/0149-7634(95)00046-h
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发表时间：
1996-03-01
影响因子：
8.2
通讯作者：
Bernstein, IL
中科院分区：
文献类型：
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作者：
Bernstein, IL
肿瘤通常会导致食物摄入量和体重下降，这种情况被称为肿瘤厌食症。肿瘤坏死因子（TNF）是一种巨噬细胞源性肽，被认为是癌症、厌食症和恶病质的重要介质。我们对这种情况的动物模型的研究表明，对现有饮食的强烈习得性厌恶出现在携带植入肿瘤的大鼠中，这些厌恶显着导致食物摄入量和体重的下降。最后区和附近的孤束尾侧内侧核（APcmNTS）的损伤显着减弱了习得性厌恶和肿瘤生长诱导的厌食症。肿瘤引起的厌恶和厌食症的影响模式惊人的相似，被认为是后迷走神经切断术和辣椒素治疗。所有三种治疗的效果相似，表明它们涉及中断相同的系统，推测是由迷走神经传递到孤束核的传入信号。还检查了外周TNF给药产生与肿瘤生长产生的症状相似的症状的程度。TNF给药与强烈厌恶一种新的但不是熟悉的饮食的发展有关。发现最后区病变可显著减弱TNF对新饮食摄入和偏好的影响。这些观察结果提供了TNF的影响和肿瘤生长对饮食厌恶和食物摄入的影响之间的相似之处。
Tumors often cause declines in food intake and body weight, a condition referred to as tumor anorexia. A macrophagederived peptide known as tumor necrosis factor (TNF) has been proposed as an important mediator of cancer anorexia and cachexia. Our work with an animal model of this condition indicates that strong learned aversions to the available diet arise in rats bearing implanted tumors and that these aversions contribute significantly to depressions in food intake and body weight. Lesions of the area postrema and nearby caudal medial nucleus of the solitary tract (APcmNTS) markedly attenuate both the learned aversions and the anorexia induced by tumor growth. A strikingly similar pattern of effects on tumor-induced aversions and anorexia was seen after subdiaphragmatic vagotomy and after capsaicin treatments. The similarity in the effects of all three treatments suggests that they involve interruption of the same system, presumably afferent signals conveyed by the vagus nerve to the nucleus of the solitary tract. The extent to which peripheral TNF administration generates symptoms similar to those produced by tumor growth was also examined. TNF administration was associated with the development of strong aversions to a novel but not a familiar diet. Area postrema lesions were found to significantly attenuate the effects of TNF on novel diet intake and preference. These observations provide parallels between the effects of TNF and the effects of tumor growth on diet aversions and food intake.