Neuropsychological functioning in elderly patients with schizophrenia and Alzheimer's disease
Neuropsychological functioning in elderly patients with schizophrenia and Alzheimer's disease
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DOI：
10.1016/s0920-9964(01)00232-8
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发表时间：
2002-06-01
影响因子：
4.5
通讯作者：
Gur, RE
中科院分区：
文献类型：
--
作者：
McBride, T;Moberg, PJ;Gur, RE
采用简单的神经心理学成套测验，对老年精神分裂症患者、老年阿尔茨海默病（AD）患者和匹配的健康对照者的认知功能进行了比较。与对照组相比，精神分裂症和AD患者表现出明显的损害，这两种疾病的神经心理缺陷的轮廓出现显着相似。只有视觉对抗命名，言语延迟回忆，遗忘率（即储蓄分数）显着区别于两个患者组，与AD患者表现出较差的整体回忆和更快的遗忘言语信息延迟。此外，精神分裂症的主题显示出显着更大的赤字在视觉对抗命名比AD组。精神分裂症患者的神经心理功能与临床症状的关系也进行了研究。结果表明，字表学习，延迟回忆，遗忘率与阳性和阴性症状的相关性最强。最近的神经病理学研究表明，精神分裂症海马结构的特定子领域的异常也严重影响AD。虽然这两种疾病的具体组织病理学不同，但共同部位的异常可能是共同的神经心理学特征的基础。(C)2002 Elsevier Science B.V.保留所有权利。
Cognitive functioning was compared in elderly patients with schizophrenia, elderly patients with probable Alzheimer's disease (AD), and matched healthy controls using a brief neuropsychological battery. Both schizophrenia and AD patients demonstrated marked impairment as compared to controls, with the profile of neuropsychological deficits in both disorders appearing remarkably similar. Only visual confrontation naming, verbal delayed recall, and rate of forgetting (i.e. savings score) significantly differentiated between the two patient groups, with AD patients showing poorer overall recall and more rapid forgetting of verbal information over delay. In addition, schizophrenia subjects showed a significantly greater deficit in visual confrontation naming than the AD group. The relationship of neuropsychological function and clinical symptoms of schizophrenia subjects was also examined. Results showed that word list learning, delayed recall, and rate of forgetting correlated most strongly with positive and negative symptoms. Recent neuropathological studies have indicated abnormalities in specific subfields of the hippocampal formation in schizophrenia that are also severely affected in AD. Though the specific histopathology of the two disorders differs, abnormalities in the common sites may underlie the common neuropsychological profile. (C) 2002 Elsevier Science B.V. All rights reserved.