Peripheral T-cell lymphomas. Clinico-pathologic study of 168 cases diagnosed according to the REAL classification
Peripheral T-cell lymphomas. Clinico-pathologic study of 168 cases diagnosed according to the REAL classification
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DOI：
10.1023/a:1008200307625
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发表时间：
1997-06-01
影响因子：
50.5
通讯作者：
Pileri, SA
中科院分区：
文献类型：
--
作者：
Ascani, S;Zinzani, PL;Pileri, SA
背景。根据修订后的欧美淋巴瘤 (R.E.A.L.) 分类对 168 例外周 T 细胞淋巴瘤 (PTCL) 进行了审查。患者和方法。这些病例最初是根据更新的基尔分类（UKC）诊断的，均提供了组织学准备、免疫表型临床信息和随访数据。五名观察员将 R.E.A.L 标准与细胞大小测量相结合，对载玻片进行了重新分类。通过单变量和多变量分析评估临床和病理结果的预后价值。结果。 R.E.A.L.所有观察者都可重复应用分类。临床上，间变性大细胞淋巴瘤 (ALCL) 与其余 PTCL 的差异在于平均年龄（29.5 岁 vs. 52.9 岁）、大块病变（52.3% vs. 11.3%；P = 0.000）、纵隔肿块（52.7% vs. 32%；P = 0.004）和无病生存率（68.0% vs. 11.3%；P = 0.000）。 38.2%；P = 0.0001)。尽管每种组织学类型都表现出特定的临床特征，但除 ALCL 之外的 PTCL 的基本特征是临床结果较差，且不受 UKC 恶性分级的影响。在多变量分析中，完全缓解率较低的风险与大块疾病 (P < 0.001)、组织学分组 (非 ALCL) (P = 0.01) 和晚期 (III-IV) (P = 0.0002) 有关。结论。本研究支持 R.E.A.L. 提出的 T 细胞淋巴瘤分类。方案。
Background. One hundred sixty-eight peripheral T-cell lymphomas (PTCLs) were reviewed according to the Revised European-American Lymphoma (R.E.A.L.) Classification.Patients and methods. The cases, originally diagnosed on the basis of the Updated Kiel Classification (UKC), were all provided with histological preparations, immunophenotype clinical information: and follow-up data. The slides were reclassified by five observers, who integrated the R.E.A.L criteria with cell size measurements. The prognostic value of clinical and pathologic findings was assessed by univariate and multivariate analysis.Results. The R.E.A.L. Classification was reproducibly applied by all of the observers. Clinically, anaplastic large cell lymphomas (ALCLs) differed from the remaining PTCLs by mean age (29.5 vs. 52.9 years), bulky disease (52.3% vs. 11.3%; P = 0.000), mediastinal mass (52.7% vs. 32%; P = 0.004), and disease-free survival(68.0% vs. 38.2%; P = 0.0001). Although each histological type displayed specific clinical aspects, PTCLs other than ALCL were basically characterised by a poor clinical outcome which was not influenced by the UKC malignancy grade. At multivariate analysis, the risk of a lower complete remission rate was related to bulky disease (P 0.001), histologic group (non-ALCL) (P = 0.01), and advanced stage (III-IV) (P = 0.0002).Conclusions. The present study supports the classification of T-cell lymphomas proposed by the R.E.A.L. scheme.