Administration of an inhibitor of estrogen biosynthesis facilitates working memory acquisition in male rats
Administration of an inhibitor of estrogen biosynthesis facilitates working memory acquisition in male rats
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DOI：
10.1016/j.neures.2007.03.011
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发表时间：
2007-07-01
影响因子：
2.9
通讯作者：
Gonzalez-Burgos, Ignacio
中科院分区：
文献类型：
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作者：
Alejandre-Gomez, Misael;Garcia-Segura, Luis Miguel;Gonzalez-Burgos, Ignacio
已知雌二醇可以改善雌性动物和绝经后妇女的一些工作记忆任务的表现。在女性中，雌二醇的主要来源是卵巢。此外，在雄性和雌性中，雌二醇都是在腺外组织中合成的。非卵巢雌二醇合成对认知能力的作用尚未得到充分的探讨。在本研究中，我们评估了芳香化酶抑制剂对雄性大鼠自我中心工作记忆的影响。芳香化酶是一种从睾酮中产生雌二醇的酶。Sprague-Dawley成年雄性大鼠食管内给予芳香化酶抑制剂来曲唑（2.5 mg/kg）或对照物。当在交叉臂迷宫中进行测试时，用芳香酶抑制剂治疗的大鼠比未治疗的动物或用交通工具治疗的动物犯的错误更少。保留和提取阶段不受芳香酶抑制的影响。这一发现表明芳香化酶活性与自我中心工作记忆表现有关。芳香化酶抑制剂对工作记忆的影响可能是由于芳香化酶抑制导致睾酮水平增加或大脑中雌二醇可用性的改变。(C) 2007爱思唯尔爱尔兰有限公司和日本神经科学学会。版权所有。
Estradiol is known to improve performance of some working memory tasks in female animals and post-menopausal women. In females the main source of estradiol is the ovary. In addition, in both males and females estradiol is synthesized in extragonadal tissues. The role of non-ovarian estradiol synthesis on cognitive abilities has not been adequately explored. In the sent study we have assessed the effect of an inhibitor of aromatase, the enzyme that produces estradiol from testosterone, on egocentric working memory in male rats. Sprague-Dawley adult male rats received the intra-esophageal administration of the aromatase inhibitor letrozole (2.5 mg/kg), or vehicle. Rats treated with the aromatase inhibitor committed less errors than untreated animals or animals treated with vehicle, when tested in a cross-arms maze. Retention and retrieval stages were unaffected by aromatase inhibition. This finding indicates that aromatase activity is involved in egocentric working memory performance. The effect of the aromatase inhibitor on working memory may be due to the increase in testosterone levels resulting from aromatase inhibition or to modifications in the availability of estradiol in the brain. (C) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.