Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population
Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population
复制标题
DOI：
10.1007/s00125-007-0618-z
复制
发表时间：
2007-05-01
期刊：
影响因子：
8.2
通讯作者：
Maeda, S.
中科院分区：
文献类型：
--
作者：
Hayashi, T.;Iwamoto, Y.;Maeda, S.
目的/假设是转录因子7样基因（TCF7L2）已被证明与白人人群中2型糖尿病的风险增加密切相关。为了进一步研究TCF7L2参与对2型糖尿病的敏感性，我们研究了日本人群中TCF7L2多态性与2型糖尿病的关联。我们分析了四个SNPS（RS12255372，RS7903146，RSS799055）和方法repeat polymorphism (DG10S478) in 1,630 Japanese subjects with type 2 diabetes and 1,064 control subjects.Results All investigated polymorphisms were significantly associated with type 2 diabetes, and rs12255372 showed the strongest association (T vs G, chi(2) = 9.20, p = 0.0024，优势比= 1.70，95％CI = 1.20-2.41），尽管我们人口中风险等位基因的频率远低于白人人群的频率。当将重复较长的等位基因（+8，+12）视为次要等位基因时，微卫星多态性几乎完全连接与卢比的连接不平衡，并显示为次要等位基因，并且显示与2型糖尿病相关（CHI（2）= 5.34，P = 0.021，赔率，赔率，赔率，赔率，赔率，赔率比率= 1.50，95％CI = 1.06-2.12）。结论/解释这些结果表明，TCF7L2可能是赋予不同种族跨越2型糖尿病的易感性的有力候选者。
Aims/hypothesis The transcription factor 7-like 2 gene (TCF7L2) has been shown to be strongly associated with an increased risk of type 2 diabetes in white populations. To further investigate the involvement of TCF7L2 in conferring susceptibility to type 2 diabetes, we examined the association of TCF7L2 polymorphisms with type 2 diabetes in a Japanese population.Subjects and methods We analysed four SNPs (rs12255372, rs7903146, rs7901695 and rs11196205) and one tetranucleotide repeat polymorphism (DG10S478) in 1,630 Japanese subjects with type 2 diabetes and 1,064 control subjects.Results All investigated polymorphisms were significantly associated with type 2 diabetes, and rs12255372 showed the strongest association (T vs G, chi(2) = 9.20, p = 0.0024, odds ratio = 1.70, 95% CI = 1.20-2.41), although the frequency of the risk allele in our population was much lower than that in white populations. The microsatellite polymorphism showed an almost complete linkage disequilibrium to rs1255372 when the alleles with longer repeats (+8, +12) were considered as minor alleles and showed an association with type 2 diabetes (chi(2) = 5.34, p = 0.021, odds ratio = 1.50, 95% CI = 1.06-2.12).Conclusions/interpretation These results indicate that TCF7L2 might be a strong candidate for conferring susceptibility to type 2 diabetes across different ethnicities.