Antibacterial peptides for therapeutic use: obstacles and realistic outlook
Antibacterial peptides for therapeutic use: obstacles and realistic outlook
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DOI：
10.1016/j.coph.2006.04.006
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发表时间：
2006-10-01
影响因子：
4
通讯作者：
Hancock, Robert E. W.
中科院分区：
文献类型：
--
作者：
Marr, Alexandra K.;Gooderham, William J.;Hancock, Robert E. W.
阳离子抗菌肽是几乎所有生命物种产生的，作为其对感染的直接非特异性防御的组成部分。这些肽在临床应用中的优点包括它们的广谱活性、快速杀菌活性和低抗性发展倾向的潜力，而可能的缺点包括它们的高成本、有限的稳定性（特别是当由L-氨基酸组成时）和未知的毒理学和药代动力学。随着稳定的、更具成本效益的和有效的广谱合成肽的开发，他们成功的最初障碍正日益被克服。因此，有希望它们将产生新一代的抗微生物剂，具有广泛的局部和全身应用以对抗感染。
Cationic antimicrobial peptides are produced by almost all species of life as a component of their immediate non-specific defense against infections. The assets of these peptides in clinical application include their potential for broad-spectrum activity, rapid bactericidal activity and low propensity for resistance development, whereas possible disadvantages include their high cost, limited stability (especially when composed of L-amino acids), and unknown toxicology and pharmacokinetics. Initial barriers to their success are being increasingly overcome with the development of stable, more cost-effective and potent broad-spectrum synthetic peptides. Thus, there is hope that they will spawn a new generation of antimicrobials with a broad range of topical and systemic applications against infections.