Siglecs in innate immunity
Siglecs in innate immunity
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DOI：
10.1016/j.coph.2005.03.003
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发表时间：
2005-08-01
影响因子：
4
通讯作者：
Crocker, PR
中科院分区：
文献类型：
--
作者：
Crocker, PR
Siglecs是以高度特异性的方式表达的唾液酸结合igg样凝集素，涉及信号传导和粘附功能。cd33相关的siglecs代表了先天免疫系统中正在快速进化的一个独特的亚群，具有触发细胞凋亡和提供抑制信号的潜力。CD22是一种特性良好的B细胞限制性siglec，已被证明在B细胞调节中介导唾液酸依赖和独立的信号功能。作为内吞受体，siglecs为某些病毒和细菌病原体提供了进入的门户，也为疾病中靶向先天免疫细胞提供了治疗机会。
Siglecs are sialic acid-binding Ig-like lectins expressed in a highly specific manner, and which are implicated in signaling and adhesive functions. The CD33-related siglecs represent a distinct subgroup that is undergoing rapid evolution within the innate immune system, with the potential to trigger apoptosis and provide inhibitory signals. CD22 is a well-characterised B cell restricted siglec that has been shown to mediate both sialic acid-dependent and independent signaling functions in B cell regulation. As endocytic receptors, siglecs provide portals of entry for certain viral and bacterial pathogens, as well as therapeutic opportunities for targeting innate immune cells in disease.