Infectious SARS-CoV-2 Is Emitted in Aerosol Particles.
Infectious SARS-CoV-2 Is Emitted in Aerosol Particles.
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DOI：
10.1128/mbio.02527-21
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发表时间：
2021-10-26
期刊：
影响因子：
6.4
通讯作者：
Duggal NK
中科院分区：
文献类型：
--
作者：
Hawks SA;Prussin AJ 2nd;Kuchinsky SC;Pan J;Marr LC;Duggal NK
呼吸道病毒如SARS-CoV-2通过呼吸道飞沫和气溶胶颗粒传播，在说话、呼吸、咳嗽和打喷嚏时释放。SARS-CoV-2的非接触性传播已得到证实，表明通过空气携带的病毒传播。在这里，我们证明了金黄色的叙利亚仓鼠产生传染性SARS-CoV-2的气溶胶颗粒之前，并同时与轻微的临床症状的疾病发作。在本研究中，接种后第1天和第2天的平均排放速率为25个感染性病毒粒子/小时，平均病毒RNA水平比气溶胶颗粒中的感染性病毒高200倍。大部分病毒包含在小于5 μm的颗粒中。因此，我们提供了直接的证据表明，在仓鼠中，SARS-CoV-2是一种空气传播的病毒。
Respiratory viruses such as SARS-CoV-2 are transmitted in respiratory droplets and aerosol particles, which are released during talking, breathing, coughing, and sneezing. Noncontact transmission of SARS-CoV-2 has been demonstrated, suggesting transmission via virus carried through the air. Here, we demonstrate that golden Syrian hamsters produce infectious SARS-CoV-2 in aerosol particles prior to and concurrent with the onset of mild clinical signs of disease. The average emission rate in this study was 25 infectious virions/hour on days 1 and 2 postinoculation, with average viral RNA levels 200-fold higher than infectious virus in aerosol particles. The majority of virus was contained within particles <5 μm in size. Thus, we provide direct evidence that, in hamsters, SARS-CoV-2 is an airborne virus.