A comparative genetic map of rat, mouse and human genomes.
A comparative genetic map of rat, mouse and human genomes.
复制标题
大鼠、小鼠和人类基因组的比较遗传图谱。
作者：
Tadao Serikawa;Zonghu Cui;N. Yokoi;T. Kuramoto;Y. Kondo;K. Kitada;J. Guénet
越来越多的可用性的分子标记和高效的基因作图策略的小鼠，大鼠和人类基因组的发展产生了大量的信息，允许比较地图的逐步完善。在本出版物中，我们报告了我们的大鼠/小鼠/人类比较遗传图谱的更新版本，基于小鼠图谱。小鼠，大鼠和人类基因定位数据库被用于收集在物种中映射的同源物。用总共1，235个在大鼠和/或人中具有已知同源物的小鼠基因座构建比较图谱：16个仅在大鼠中具有同源物，884个仅在人中具有同源物，335个在大鼠和人中均具有同源物。大鼠和小鼠之间保守的片段的组合长度在小鼠图谱上跨越758 cM。这表明大约47%的小鼠基因组现在被已知的大鼠同源区域覆盖。确定了与大鼠和小鼠同源的五个新区域。这一比较遗传图谱对从事大鼠、小鼠和人类遗传研究的研究人员应该是有用的。
The increasing availability of molecular markers and the development of highly efficient gene mapping strategies for the mouse, rat and human genomes have generated vast quantities of information allowing for the progressive refinement of comparative maps. In this publication we report on an updated version of our rat/mouse/human comparative genetic map, based on the mouse map. Databases for mouse, rat and human gene mapping were used for the collection of homologs mapped in the species. The comparative map was constructed with a total of 1,235 mouse loci having known homologs in the rat and/or human: 16 having homologs only in the rat, 884 having only in the human and 335 both in the rat and human. The combined length of the segments conserved between the rat and mouse spans 758 cM on the mouse map. This indicates that about 47% of the mouse genome is now covered by known rat homologous regions. Five novel regions homologous for the rat and mouse were identified. This comparative genetic map should be useful for researchers working on genetic studies in the rat, mouse and human.