Association of sex hormones with incident 10-year cardiovascular disease and mortality in women
Association of sex hormones with incident 10-year cardiovascular disease and mortality in women
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DOI：
10.1016/j.maturitas.2015.08.009
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发表时间：
2015-12-01
期刊：
影响因子：
4.9
通讯作者：
Haring, Robin
中科院分区：
文献类型：
--
作者：
Schaffrath, Gotja;Kische, Hanna;Haring, Robin
目的：这项研究的目的是确定血清总睾酮(TT)水平高或性激素结合球蛋白(SHBG)水平低的女性更容易患心血管疾病(CVD)，并调查性激素与普通人群死亡率(全因和特定原因)之间的潜在关联。研究设计和主要观察指标：2129名平均年龄49.0岁的女性的数据来自于波美拉尼亚基于人群的健康研究，平均随访时间为10.9年。用多元回归模型分析基线水平、TT、SHBG、雌二酮(ASD)、游离睾酮(FT)和游离雄激素指数(FAI)与心血管疾病发病率、全因和心血管疾病死亡率的关系。结果：基线时378名女性的心血管疾病患病率为17.8%，随访期间心血管疾病的发病率为50.9/1000人年。在年龄调整的模型中，我们发现SHBG和基线心血管疾病之间存在负相关(每标准差增加的相对风险：0.83；95%可信区间：0.74-0.93)。在年龄和多变量调整的泊松回归模型中，我们没有发现性激素浓度和心血管事件之间有任何显著的关联。此外，没有一种性激素(TT、SHBG、ASD、17、FAI)与全因死亡相关。结论：这项基于人群的队列研究没有得出女性性激素与心血管疾病或死亡风险之间的任何一致的关联。(C)2015爱思唯尔爱尔兰有限公司。保留所有权利。
Objectives: The aims of this study were to ascertain whether women with high levels of serum total testosterone (TT) or low levels of sex hormone-binding globulin (SHBG) are more likely to develop cardiovascular disease (CVD), and to investigate potential associations between sex hormones and mortality (all-cause, as well as cause-specific) in the general population.Study design and main outcome measures: Data on 2129 women with a mean age of 49.0 years were obtained from the population-based Study of Health in Pomerania over a median follow-up of 10.9 years. Associations of baseline levels of TT, SHBG, and rostenedione (ASD), and free testosterone (fT), and of the free androgen index (FAI), with follow-up CVD morbidity, as well as all-cause and CVD mortality, were analyzed using multivariable regression modeling.Results: At baseline the prevalence rate of CVD was 17.8% (378 women) and the incidence of CVD over the follow-up was 50.9 per 1000 person-years. We detected an inverse association between SHBG and baseline CVD in age-adjusted models (relative risk per standard deviation increase: 0.83; 95% confidence interval: 0.74-0.93). We did not detect any significant associations between sex hormone concentrations and incident CVD in age- and multivariable-adjusted Poisson regression models. Furthermore, none of the sex hormones (TT, SHBG, ASD,17, FAI) were associated with all-cause mortality.Conclusions: This population-based cohort study did not yield any consistent associations between sex hormones in women and incident CVD or mortality risk. (C) 2015 Elsevier Ireland Ltd. All rights reserved.