Coexistent chronic conditions and asthma quality of life - A population-based study
Coexistent chronic conditions and asthma quality of life - A population-based study
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DOI：
10.1378/chest.129.2.285
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发表时间：
2006-02-01
期刊：
影响因子：
9.6
通讯作者：
Ruffin, RE
中科院分区：
文献类型：
--
作者：
Adams, RJ;Wilson, DH;Ruffin, RE
目的：关于哮喘患者中共病的患病率和影响的报告仅限于某些人群或方便样本。我们的目的是研究哮喘的主要合并症的患病率和协会的生活质量和功能状态在一般population.Study设计/设置：WANTS的健康和福祉调查是一个横截面的代表性人口家庭电话采访调查在澳大利亚的三个州。参会人员：非制度化的成年人在澳大利亚三个state.Measurement和结果的代表性样本：从现有的样本10,080例患者，7,619访谈完成（参与率，74.8%），与834人报告目前医生诊断的哮喘（11.2%）。哮喘患者更有可能报告一种选定的共病：糖尿病，关节炎，心脏病，中风，癌症，骨质疏松症（调整后的比值比，1.9; 95%置信区间，1.5至2.2）。在哮喘患者中，当另一种慢性疾病也存在时，日常活动水平和简表-12身体成分汇总评分在统计学和临床上显著降低。对于那些与任何的慢性疾病，哮喘的额外存在与显着的进一步损害，在那些年龄> 35岁的生活质量，但不是在年轻adult.Conclusion：在生活质量的显着降低与合并症哮喘的影响疾病管理和组织的护理，以及设计和外部效度的单疾病临床试验。
Objective: Reports of the prevalence and impact of comorbid conditions among people with asthma have been limited to certain population groups or convenience samples. Our aim was to examine the prevalence of major comorbidity in asthma and associations with quality of life and functional status in the general population.Study design/setting: The WANTS Health and Well-being Survey is a cross-sectional representative population household telephone interview survey in three Australian states. Participants: Representative sample of noninstitutionalized adults in three Australian states.Measurement and results: From the available sample of 10,080 patients, 7,619 interviews were completed (participation rate, 74.8%), with 834 people reporting current doctor-diagnosed asthma (11.2%). People with asthma were more likely to report one of the selected comorbid conditions: diabetes, arthritis, heart disease, stroke, cancer, osteoporosis (adjusted odds ratio, 1.9; 95% confidence interval, 1.5 to 2.2). Among people with asthma, there were statistically and clinically significant decreases in usual activity levels and in Short Form-12 physical component summary scores when another chronic condition was also present. For those with any of the chronic conditions, the additional presence of asthma was associated with significant further impairment in quality of life in those aged > 35 years but not in younger adults.Conclusion: The significant reduction in quality of life associated with comorbidity in asthma has implications for disease management and organization of care, as well as for the design and external validity of single-disease clinical trials.