Knockdown of Histone Methyltransferase WHSC1 Induces Apoptosis and Inhibits Cell Proliferation and Tumorigenesis in Salivary Adenoid Cystic Carcinoma
Knockdown of Histone Methyltransferase WHSC1 Induces Apoptosis and Inhibits Cell Proliferation and Tumorigenesis in Salivary Adenoid Cystic Carcinoma
复制标题
敲低组蛋白甲基转移酶 WHSC1 诱导唾液腺腺样囊性癌细胞凋亡并抑制细胞增殖和肿瘤发生
DOI：
10.21873/anticanres.13399
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发表时间：
2019-06-01
影响因子：
2
通讯作者：
Zheng, Jia-Wei
中科院分区：
文献类型：
--
作者：
Liu, Chao;Jiang, Yu-Hang;Zheng, Jia-Wei
Background/Aim: Salivary adenoid cystic carcinoma (SACC) is the most common malignancy of the salivary gland with a poor prognosis and survival. The present study aimed to investigate the role of histone methyltransferase WHSC1 in SACC. Materials and Methods: Human SACC specimens were evaluated for WHSC1 expression by RT-PCR and immunohistochemistry. The effects of WHSC1 knockdown on SACC cells proliferation, cell cycle, clone and tumorsphere formation, and apoptosis as well as on the expression of related genes were examined. A xenograft mouse model of SACC was used to evaluate the in vivo effects of WHSC1 knockdown on SACC tumorigenesis. Results: WHSC1 expression was up-regulated in human SACC tissues (p
