The tumor-suppressive and potential therapeutic functions of miR-34a in epithelial carcinomas.
The tumor-suppressive and potential therapeutic functions of miR-34a in epithelial carcinomas.
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DOI：
10.1517/14728222.2016.1114102
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发表时间：
2016-06
影响因子：
5.8
通讯作者：
Slack FJ
中科院分区：
文献类型：
--
作者：
Adams BD;Parsons C;Slack FJ
许多RNA种类已被确定为包括癌症在内的慢性疾病发展的重要参与者。某些类别的调节RNA如miRNA已经被详细研究，从而已经鉴定出真正的肿瘤抑制和致癌miRNA。正因为如此，人们一直在努力治疗靶向这些小RNA。特别是一种miR-34 a（MRX 34）的脂质体制剂已进入I期试验。这篇综述旨在总结miRNA的生物学，其在正常与疾病状态下的调节，以及如何靶向治疗，特别强调miR-34 a。了解单个miRNA的复杂性将有助于开发未来基于RNA的治疗方法，用于更广泛的慢性疾病。miRNAs被开发成抗癌疗法的潜力已成为越来越重要的研究领域。miR-34 a是一种跨多种肿瘤类型的肿瘤抑制性miRNA，其抑制细胞增殖、侵袭和肿瘤球形成的能力。miR-34 a在某些体内实体瘤模型中也显示出前景。最后，随着miR-34 a进入临床试验，重要的是确定它是否可以进一步使肿瘤对某些化疗药物敏感。
Many RNA species have been identified as important players in the development of chronic diseases including cancer. Certain classes of regulatory RNAs such as miRNAs have been investigated in such detail that bona fide tumor suppressive and oncogenic miRNAs have been identified. Because of this, there has been a major effort to therapeutically target these small RNAs. One in particular, a liposomal formulation of miR-34a (MRX34), has entered Phase I trials. This review aims to summarize miRNA biology, its regulation within normal versus disease states, and how it can be targeted therapeutically, with a particular emphasis on miR-34a. Understanding the complexity of a single miRNA will aid in the development of future RNA-based therapeutics for a broader range of chronic diseases. The potential of miRNAs to be developed into anti-cancer therapeutics has become an increasingly important area of research. miR-34a is a tumor suppressive miRNA across many tumor types through its ability to inhibit cellular proliferation, invasion, and tumor sphere formation. miR-34a also shows promise within certain in vivo solid tumor models. Finally, as miR-34a moves into clinical trials it will be important to determine if it can further sensitize tumors to certain chemotherapeutic agents.