Fiber number, area, and composition of mouse soleus muscle following enlargement.
Fiber number, area, and composition of mouse soleus muscle following enlargement.
复制标题
小鼠比目鱼肌增大后的纤维数量、面积和成分。
DOI：
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发表时间：
1985
影响因子：
3.3
通讯作者：
J. B. George
中科院分区：
文献类型：
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作者：
B. Timson;B. Bowlin;G. Dudenhoeffer;J. B. George
研究了小鼠比目鱼肌纤维数量、横截面积和组成对协同消融产生的扩大的反应。用小鼠比目鱼肌研究了组织学切片的位置对切片中出现的纤维数量的影响。通过切除同侧腓肠肌，15只雄性和15只雌性小鼠的比目鱼肌出现肿大。用硝酸消化法进行的纤维计数显示，雄性和雌性小鼠的肌肉在控制和扩大之间没有差异。通过平面测量，雄性和雌性小鼠的平均纤维面积分别增加了49.1%和34.5%。肌肉重量的增加完全可以由增大后纤维面积的增加来解释。两性扩大后，II型纤维向I型纤维转化。组织学切片的纤维计数显示，随着切片从腹部移动到肌肉远端，纤维数量逐渐减少。这些研究结果表明，小鼠比目鱼肌的肌肉扩大是由于现有肌肉纤维的肥大。
Muscle fiber number, cross-sectional area, and composition were studied in response to enlargement produced by synergistic ablation in the mouse soleus muscle. The effect of the location of a histological section on the number of fibers that appear in the section was also studied using the mouse soleus muscle. Enlargement was produced in the soleus muscle of 15 male and 15 female mice by ablation of the ipsilateral gastrocnemius muscle. Fiber counts, using the nitric acid digestion method, revealed no difference between control and enlarged muscles in male and female mice. Mean fiber area, determined by planimetry, was 49.1 and 34.5% greater following enlargement in male and female mice, respectively. Increase in muscle weight could be totally accounted for by the increase in fiber area following enlargement. A transformation of type II to type I fibers occurred following enlargement for both sexes. Counts of fibers from histological sections revealed that there was a progressive decrease in the fiber number as the section was moved from the belly to the distal end of the muscle. The results of these studies indicate that muscle enlargement in the mouse soleus muscle is due to hypertrophy of the existing muscle fibers.