The dopamine system in idiopathic generalized epilepsies: Identification of syndrome-related changes
The dopamine system in idiopathic generalized epilepsies: Identification of syndrome-related changes
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DOI：
10.1016/j.neuroimage.2010.02.051
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发表时间：
2010-06-01
期刊：
影响因子：
5.7
通讯作者：
Savic, Ivanka
中科院分区：
文献类型：
--
作者：
Ciumas, Carolina;Wahlin, Tarja-Brita Robins;Savic, Ivanka
本研究采用正电子发射断层显像（PET）和多巴胺转运蛋白（DAT）配体[C-11] PE 2 I对13例特发性全身性癫痫（ICE）、13例单纯强直阵挛性癫痫（GTCS）、13例单纯肌阵挛性癫痫（JME）和13例单纯强直阵挛性癫痫（GTCS）患者的多巴胺（DA）系统进行了研究。12名健康对照。在尾状核、壳核和中脑中定量DAT的结合电位（BP）。通过将局部血压与一系列神经心理学测试中的测试表现相关联，评估了对功能的可能影响。JME患者的中脑示踪剂结合低于对照组（0.8 +/- 0.1 vs. 1.0 +/- 0.2，p = 0.019），而GTCS患者的壳核示踪剂结合减少（5.9 +/- 1.6 vs. 7.1 +/- 1.2，p = 0.023）。而GTCS患者在运动功能和一项执行功能测试中表现出受损。JME患者在工作记忆测试和执行功能测试中也表现不佳。GTCS和JME中似乎都存在DA系统的改变。然而，这些变化的区域分布在两种综合征之间不同，它们与精神和工作记忆表现的关系也不同。目前的数据表明，这两种形式的ICE有不同的神经基板。爱思唯尔公司出版
The present study tests the hypothesis that the dopamine system is altered in idiopathic generalized epilepsy (ICE), and that the pattern of possible changes differs between juvenile myoclonic epilepsy (JME) and epilepsy with tonic-clonic seizures only (GTCS).The dopamine (DA) system was investigated with PET and a DA transporter (DAT) ligand [C-11]PE2I in 13 patients with JME, 13 with GTCS, and 12 healthy controls. The binding potential (BP) to DAT was quantified in the caudate, putamen, and midbrain. The possible impact on function was evaluated by correlating regional BP with test performance in a battery of neuropsychological tests.Both patient groups showed a reduced BP compared to controls, albeit in different locations. JME patients had a lower tracer binding than controls in the midbrain (0.8 +/- 0.1 vs. 1.0 +/- 0.2, p = 0.019), whereas GTCS patients had reduced tracer binding in the putamen (5.9 +/- 1.6 vs. 7.1 +/- 1.2, p = 0.023). While GTCS patients showed impaired performance in motor functions and on one test of executive function. JME patients performed poorly also in tests of working memory and several tests of executive function.Alterations in the DA system seem to exist in both GTCS and JME. However, the regional distribution of these changes differs between the two syndromes, as does their association with psychomotor and working memory performance. The present data suggest that the two forms of ICE have different neuronal substrates. Published by Elsevier Inc.