The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli.
The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli.
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DOI：
10.1038/ncomms9886
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发表时间：
2015-12-01
影响因子：
16.6
通讯作者：
Sacchetti B
中科院分区：
文献类型：
--
作者：
Grosso A;Cambiaghi M;Renna A;Milano L;Roberto Merlo G;Sacco T;Sacchetti B
感觉皮层参与情绪记忆，但其作用尚不清楚。本研究表明，在早期记忆巩固过程中，大鼠高阶听觉皮层Te2的失活会损害远端一级和二级恐惧记忆，但不会损害两种中性线索之间的联系。此外，Te2失活阻止了这些信息的价态变化。当两种听觉线索与愉悦或痛苦的刺激配对后，大部分细胞对两种体验都有反应，但也有一小部分神经元只对其中一种做出反应。后一种类型的神经元发出与刺激相关的效价而不是显著性或运动反应的信号，并反映选择性联想过程。记忆激活神经元的药物遗传学沉默导致健忘症。因此，Te2是将情感价值分配给感官刺激和存储这些信息的关键节点。听觉皮层Te2是啮齿动物将情感价值分配给感官刺激的关键节点。利用药物遗传学方法，本研究表明，在Te2中存在对声音的情绪效价作出反应的神经元，它们的失活损害了情绪记忆的检索。
The sensory cortex participates in emotional memory but its role is poorly understood. Here we show that inactivation of the higher order auditory cortex Te2 in rats during early memory consolidation impairs remote first- and second-order fear memories but not the association between two neutral cues. Furthermore, Te2 inactivation prevents changes in the valence of such information. Following the presentation of two auditory cues previously paired with either pleasant or painful stimuli, a large percentage of cells responds to both experiences but also a small fraction of neurons responds exclusively to one of them. The latter type of neurons signals the valence rather than the salience or the motor responses associated with the stimuli, and reflects selective associative processes. Pharmacogenetic silencing of memory-activated neurons causes amnesia. Thus, Te2 represents a crucial node for the assignment of the affective value to sensory stimuli and for the storage of such information. The auditory cortex Te2 represents a key node for the assignment of the affective value to sensory stimuli in rodents. Using pharmacogenetic manipulations, this study shows that in Te2 there are neurons which respond to the emotional valence of sounds and their inactivation impairs emotional memories retrieval.