Hepatic Stellate Cells in Inflammation-Fibrosis-Carcinoma Axis
Hepatic Stellate Cells in Inflammation-Fibrosis-Carcinoma Axis
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DOI：
10.1002/ar.21173
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发表时间：
2010-09-01
影响因子：
2
通讯作者：
Bian, Huijie
中科院分区：
文献类型：
--
作者：
Wang, Bin-Bin;Cheng, Jun-Yao;Bian, Huijie
Almost 80% of hepatocellular carcinoma (HCC) cases are associated with chronic hepatitis and cirrhosis resulting from inflammation and fibrosis. A three-step process of "inflammation-fibrosis-carcinoma" is believed to be involved in hepatocarcinogenesis. The activation of hepatic stellate cells (HSCs) may serve as an important mediator in the process of inflammation-fibrosis-carcinoma axis, even in tumor metastasis. A remarkable knowledge of activated HSCs in the pathology of HCC development is mostly focused on the liver fibrosis. The molecular links that connects inflammation and cancer in the activation of HSC are not completely known. This highlights urgent need to increase our understanding of the cellular and molecular mechanisms, by which activation of HSCs is involved in the hepatic inflammation, carcinogenesis, and metastasis. Anat Rec, 293:1492-1496, 2010. (C) 2010 Wiley-Liss, Inc.
