Light exposure at night, urinary 6-sulfatoxymelatonin, and serum estrogens and androgens in postmenopausal Japanese women
Light exposure at night, urinary 6-sulfatoxymelatonin, and serum estrogens and androgens in postmenopausal Japanese women
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DOI：
10.1158/1055-9965.epi-07-0656
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发表时间：
2008-06-01
影响因子：
3.8
通讯作者：
Shilmizu, Hiroyuki
中科院分区：
文献类型：
--
作者：
Nagata, Chisato;Nagao, Yasuko;Shilmizu, Hiroyuki
据推测，夜间暴露在阳光下会抑制正常夜间褪黑激素的产生和释放，从而增加循环中雌激素的水平，从而增加患乳腺癌的风险。我们根据206名绝经后日本妇女的睡眠习惯和夜班工作史，评估了血清雌激素和雄激素浓度与尿液中褪黑素的主要代谢物6-硫酸盐氧黑激素和夜间光照之间的关系。在凌晨1点或之后没有入睡的女性，其血清雌二醇水平显著较高。(褪黑素峰值的大致时间)比那些在控制协变量后睡着的人要少。在夜班工作的女性中，观察到雌酮水平显著增加。血清睾酮和硫酸脱氢表雄酮与睡眠习惯和夜班作业史无关。在凌晨1点或之后没有入睡的女性，尿液6-硫氧基黑素水平较低。周末比此时睡眠者多，但差异有统计学意义(P=0.08)。尿6-硫氧基黑素与任何血清激素水平均无明显关联。这些数据表明，夜间暴露在阳光下可能会增加绝经后女性患乳腺癌的风险。然而，褪黑素作为夜间光照和血清雌激素浓度之间的干预因素的潜在作用是模棱两可的。
It has been hypothesized that exposure to light at night increases the risk of breast cancer by suppressing the normal nocturnal increase in melatonin production and release, thereby resulting in increased levels of circulating estrogen. We assessed associations among concentrations of serum estrogen and androgen and the principal metabolite of melatonin in urine, 6-sulfatoxymelatonin, and exposure to light at night based on information regarding the sleeping habits and history of graveyard-shift work of 206 postmenopausal Japanese women. Serum estradiol level was significantly higher in women who were not asleep at or after 1:00 a.m. (the approximate time of the melatonin peak) than those who were asleep after controlling for covariates. Significantly increased estrone levels were observed in women who had worked graveyard shift. Serum testosterone and DHEA sulfate were unrelated to sleeping habits and history of graveyard-shift work. Urinary 6-sulfatoxymelatonin was lower in women who were not asleep at or after 1:00 a.m. on weekends than those who were asleep at this time, but the difference was of borderline significance (P = 0.08). There was no significant association between urinary 6-sulfatoxymelatonin and any serum hormone levels. These data suggest that exposure to light at night has implications for the risk of breast cancer in postmenopausal women. However, the potential role of melatonin as an intervening factor between light exposure at night and the serum concentrations of estrogen was equivocal.