Relation between total tear IgE and specificserum IgE in seasonal allergic conjunctivitis
Relation between total tear IgE and specificserum IgE in seasonal allergic conjunctivitis
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季节性过敏性结膜炎泪液总IgE与特异性血清IgE的关系
DOI：
10.1097/ico.0b013e3182000feb
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发表时间：
2011
期刊：
影响因子：
2.8
通讯作者：
Amano S
中科院分区：
文献类型：
--
作者：
Mimura T;Usui T;Mori M;Funatsu H;Noma H;Yamamoto H;Aixinjueluo W;Amano S
目的：最近，开发了一种基于免疫层析 (Allerwatch) 的新的总泪液免疫球蛋白 E (IgE) 商业测试。我们检查了泪液总IgE水平与特异性血清IgE之间的关系。方法：对35名过敏性结膜炎患者（过敏组）、30名年龄和性别匹配的健康对照者（对照组）和8名流行性角结膜炎患者进行前瞻性、非随机、横断面研究。所有受试者均采用 Allerwatch 试验测定总泪液 IgE 评分（0、1、2），并分别采用 Phadezym PRIST 和 CAP-RAST 系统测定 12 种吸入性过敏原的血清总 IgE 和特异性 IgE 水平。 结果：过敏组总泪液 IgE 阳性率显着高于对照组和流行性角结膜炎组（100.0% vs. 100.0%）。 0.0% 与 0.0%；P<0.00001)。在过敏组中，总泪液 IgE 评分与经过对数转换的血清总 IgE 水平（r=0.61）以及雪松花粉（r=0.35）、室内灰尘（r=0.46）、屋尘螨（r=0.49）和螨虫（r=0.36）的血清 IgE 水平显着相关。多变量逻辑回归分析显示，对数转换的总血清 IgE 水平是总泪液 IgE 评分的唯一显着预测因子（比值比 = 1.85，P = 0.00008）。结论：通过 Allerwatch 检验确定的总泪液 IgE 评分与总和特异性血清 IgE 水平相关。这种快速测试易于执行、灵敏且具有高度特异性，可用于门诊眼部过敏的检测。
Purpose:Recently, a new commercial test for total tear immunoglobulin E (IgE), based on immunochromatography (Allerwatch), was developed. We examined the relation between the total IgE level in tears and specific serum IgE.Methods:A prospective, nonrandomized, cross-sectional study was conducted in 35 patients with allergic conjunctivitis (allergic group), 30 age-and sex-matched healthy control subjects (control group), and 8 patients with epidemic keratoconjunctivitis. In all subjects, the total tear IgE score was determined with the Allerwatch test (0, 1, and 2), and serum levels of total IgE and specific IgE for 12 inhaled allergens were measured with the Phadezym PRIST and CAP-RAST systems, respectively.Results:The total tear IgE-positive rate was significantly higher in the allergic group than in the control and epidemic keratoconjunctivitis groups (100.0% vs. 0.0% vs. 0.0%; P< 0.00001). In the allergic group, the total tear IgE score was significantly correlated with the log-transformed total serum IgE level (r= 0.61) and with the serum levels of IgE for cedar pollen (r= 0.35), house dust (r= 0.46), Dermatophagoides pteronyssinus (r= 0.49), and acarus (r= 0.36). Multivariate logistic regression analysis showed that the log-transformed total serum IgE level was the only significant predictor of the total tear IgE score (odds ratio= 1.85, P= 0.00008).Conclusions:The total tear IgE score, determined with the Allerwatch test, was correlated with the total and specific serum IgE levels. This rapid test is easy to perform, sensitive, and highly specific for the detection of ocular allergy on an outpatient basis.