Minimal persistent inflammation is also present in patients with seasonal allergic rhinitis
Minimal persistent inflammation is also present in patients with seasonal allergic rhinitis
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DOI：
10.1016/s0091-6749(00)90177-5
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发表时间：
2000-01-01
影响因子：
14.2
通讯作者：
Ciprandi, G
中科院分区：
文献类型：
--
作者：
Ricca, V;Landi, M;Ciprandi, G
背景：过敏反应的特点是炎症反应，与过敏原暴露相关，即使没有症状，在螨过敏患者中也可检测到。目的：本研究旨在评估长期观察期间花粉过敏患者是否存在炎症。方法：纳入仅对白桦过敏的 6 名患者，评估参数为（1）鼻部症状，（2）炎症标志物（即中性粒细胞和嗜酸性粒细胞） (3) 花粉计数。患者在花粉季节期间每 4 天进行一次检查，持续 40 天，并在花粉季节结束后观察 3 次。结果：在整个花粉季节，即使在花粉计数规律、症状较低或没有症状的日子里，明显的炎症反应也很明显。结论：本研究结果表明，过敏性鼻炎的全球治疗策略应进行修订，并针对炎症现象，而不仅仅是症状。
Background: The allergic reaction is characterized by an inflammatory response, which is correlated to the allergon exposure, and is detectable in mite allergic patients, even when symptoms are absent.Objective: The study was aimed at assessing the presence of inflammation in patients with pollen allergy during a long observation period.Methods: Six patients, sensitized only to Betula alba, were enrolled, Evaluated parameters were (1) nasal symptoms, (2) inflammatory markers (ie, neutrophil and eosinophil number and intercellular adhesion molecule-1 expression on nasal epithelial cells), and (3) pollen count. Patients were examined during the pollen season every 4 days for 40 days and were observed 3 times after the pollen season.Results: A significant inflammatory reaction was evident throughout the pollen season, even during the days with a law pollen count and low or absent symptoms.Conclusions: The results of this study indicate that the global therapeutic strategy for allergic rhinitis should be revised and targeted to inflammatory phenomena rather than to symptoms alone.