Variations of cardiac performance and inotropism in healthy postmenopausal women treated with estroprogestin replacement therapy.
Variations of cardiac performance and inotropism in healthy postmenopausal women treated with estroprogestin replacement therapy.
复制标题
使用雌孕激素替代疗法治疗的健康绝经后妇女的心脏功能和正性肌力的变化。
DOI：
10.1097/00042192-199906010-00010
复制
发表时间：
1999
期刊：
影响因子：
2.7
通讯作者：
A. Volpe
中科院分区：
文献类型：
--
作者：
A. Gallinelli;S. Angioni;M. L. Matteo;P. Montaldo;M. Fenu;A. Volpe
目的
本研究的目的是评估与卵巢雌激素产生的自然变化有关的心脏血流动力学参数的可能变化。
方法
40例绝经后妇女，年龄52.7 ± 4.6岁，随机分为两组（每组20例），根据雌激素替代治疗（ERT）的管理（A组）和非（B组），使用胸电生物阻抗进行检查。
结果
治疗6个月后，观察到：（1）A组平均舒张末期指数明显高于B组（分别为70.27和57.13 mL/m2）（p <0.05）;（2）平均加速度指数，心脏收缩力的指标，和平均心脏指数速率，心脏性能的指标，A组明显高于B组（平均值分别为1.35与0.76秒[p <0.01]，平均值分别为3.22与2.34 L/min/m2 [p <0.05]）; ERT治疗组的体循环血管阻力指数明显低于对照组（平均值，2280 vs. 3150 fOhm/m2 [p <0.01]），在治疗6个月后达到标准水平。此外，在A组中，在ERT的第3个月和第6个月之间，加速指数显示出显著增加（0.91 vs. 1.35 s [p <0.05]）。
结论
我们的研究结果表明，绝经后妇女与6个月的ERT治疗有显着改善舒张末期指数，心脏收缩指数，心脏指数，和全身血管阻力，而3个月的ERT似乎并没有引起同样的效果。在我们的研究中，胸电生物阻抗被证明是一种灵敏和特异的分析方法，管理成本非常低。
OBJECTIVE
The aim of the present study was to evaluate possible variations in cardiac hemodynamic parameters related to the natural changes of ovarian estrogen production.
METHODS
Forty postmenopausal women aged 52.7 +/- 4.6 years, randomized into two groups (20 patients in each group) according to the administration (group A) or not (group B) of estroprogestin replacement therapy (ERT), were examined using thoracic electrical bioimpedence.
RESULTS
After 6 months of therapy, we observed the following: (1) the mean end-diastolic index was significantly higher in group A than in group B (70.27 and 57.13 mL/m2, respectively) (p < 0.05); (2) the mean acceleration index, indicator of heart contractility, and the mean cardiac index rate, indicators of cardiac performance, were significantly higher in group A than in group B (mean, 1.35 vs. 0.76 s [p < 0.01] and mean, 3.22 vs. 2.34 L/min/m2 [p < 0.05], respectively); and (3) the patients treated with ERT showed systemic vascular resistance index values significantly lower than the controls (mean, 2280 vs. 3150 fOhm/m2 [p < 0.01]), achieving standard levels after 6 months of therapy. Furthermore, the acceleration index showed a significant increase, within group A, between the third and sixth month of ERT (0.91 vs. 1.35 s [p < 0.05]).
CONCLUSIONS
Our findings suggest that postmenopausal women treated with a 6-month course of ERT have significantly improved end-diastolic index, heart contractility index, cardiac index, and systemic vascular resistance, whereas 3 months of ERT does not seem to induce the same effects. In our study, thoracic electrical bioimpedence was shown to be a sensitive and specific method of analysis with a very low cost of administration.