No effect of omeprazole on pH of exhaled breath condensate in cough associated with gastro-oesophageal reflux.
No effect of omeprazole on pH of exhaled breath condensate in cough associated with gastro-oesophageal reflux.
复制标题
奥美拉唑对胃食管反流咳嗽时呼出气冷凝物的 pH 值没有影响。
DOI：
10.1186/1745-9974-1-10
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发表时间：
2005-10-19
期刊：
影响因子：
--
通讯作者：
Chung KF
中科院分区：
文献类型：
--
作者：
Torrego A;Cimbollek S;Hew M;Chung KF
内源性气道酸化评价为呼出气冷凝液（EBC）中的pH值已在慢性咳嗽患者中描述。质子泵抑制剂改善胃食管反流（戈尔）相关咳嗽。我们检测了13例与戈尔炎相关的慢性咳嗽患者（平均年龄41岁，SD 9）在奥美拉唑治疗（40 mg/d，持续14天）前后EBC的pH值和辣椒素咳嗽反应及其与临床反应的关系。奥美拉唑消除了与戈尔相关的症状。慢性咳嗽患者在治疗前的EBC pH值为8.28（SD 0.13），但奥美拉唑治疗后未发生变化。莱斯特咳嗽问卷症状评分从80.8分（SD 13.2）显著改善至95.1分（SD 17）（p = 0.02），咳嗽评分的6分量表也有显著改善，但辣椒素咳嗽反应没有变化。与EBC pH值或辣椒素咳嗽反应的变化无关，与EBC相关咳嗽的改善。这些参数不是治疗反应的有用标志物。
Endogenous airway acidification evaluated as pH in exhaled breath condensate (EBC) has been described in patients with chronic cough. Proton pump inhibitors improve gastro-oesophageal reflux (GOR)-associated cough. We examined pH levels in EBC and capsaicin cough response in 13 patients with chronic cough (mean age 41 years, SD 9) associated with GOR before and after omeprazole treatment (40 mg/day for 14 days) and its relationship with clinical response. Omeprazole abolished symptoms associated with GOR. Patients with chronic cough had an EBC pH of 8.28 (SD 0.13) prior to treatment but this did not change with omeprazole treatment. There was a significant improvement in the Leicester Cough Questionnaire symptom scores from 80.8 points (SD 13.2) to 95.1 (SD 17) (p = 0.02) and in a 6-point scale of cough scores, but there was no change in capsaicin cough response. An improvement in GOR-associated cough was not associated with changes in EBC pH or capsaicin cough response. These parameters are not useful markers of therapeutic response.