Specialty supplements and breast cancer risk in the VITamins And Lifestyle (VITAL) Cohort.
Specialty supplements and breast cancer risk in the VITamins And Lifestyle (VITAL) Cohort.
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DOI：
10.1158/1055-9965.epi-10-0318
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
White E
中科院分区：
文献类型：
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作者：
Brasky TM;Lampe JW;Potter JD;Patterson RE;White E
近几十年来，非维生素、非矿物质“专业”补充剂的使用大幅增加。几种补充剂可能具有抗炎或抗癌特性。此外，在两项病例对照研究中，针对更年期症状服用的补充剂与乳腺癌风险降低有关。然而，还没有关于长期使用这些补充剂与乳腺癌风险之间关系的前瞻性研究。参与者是VITALs和生活方式（VITAL）队列的女性成员。2000-2002年，居住在西华盛顿州的50-76岁绝经后妇女完成了一份24页的基线调查问卷（n= 35，016）。询问参与者最近（当前与过去），频率（天/周）和专业补充剂使用的持续时间（年）。从监测、流行病学和最终结果登记处获得2000-2007年的浸润性乳腺癌发病率（n=880）。通过考克斯比例风险模型估计多变量调整的风险比（HR）和95%置信区间（95%CI）。目前使用鱼油与乳腺癌风险降低相关（HR 0.68，95% CI：0.50-0.92）。10-年平均使用表明风险降低（p趋势=0.09）。这些结果适用于导管癌，但不适用于小叶癌。其余的专业补充剂与乳腺癌风险无关：具体来说，使用补充剂有时采取更年期症状（黑升麻，当归，大豆，或圣约翰麦芽汁）与风险无关。进一步研究鱼油对乳腺癌可能的化学预防是必要的。在这些结果被复制之前，不应该推广鱼油来降低乳腺癌风险。
Use of non-vitamin, non-mineral “specialty” supplements has increased substantially over recent decades. Several supplements may have anti-inflammatory or anti-cancer properties. Additionally, supplements taken for symptoms of menopause have been associated with reduced risk of breast cancer in two case-control studies. However, there have been no prospective studies of the association between the long-term use of these supplements and breast cancer risk. Participants were female members of the VITamins And Lifestyle (VITAL) Cohort. Postmenopausal women, age 50-76 years, who were residents of western Washington State completed a 24-page baseline questionnaire in 2000-2002 (n=35,016). Participants were queried on their recency (current vs. past), frequency (days/week), and duration (years) of specialty supplement use. Incident invasive breast cancers (n=880) from 2000-2007 were obtained from the Surveillance, Epidemiology and End Results registry. Multivariable-adjusted hazards ratios (HR) and 95% confidence intervals (95% CI) were estimated by Cox proportional hazards models. Current use of fish oil was associated with reduced risk of breast cancer (HR 0.68, 95% CI: 0.50-0.92). 10-year average use was suggestive of reduced risk (p-trend=0.09). These results held for ductal but not lobular cancers. The remaining specialty supplements were not associated with breast cancer risk: specifically, use of supplements sometimes taken for menopausal symptoms (black cohosh, dong quai, soy, or St. John’s wort) was not associated with risk. Further study of fish oil for possible chemoprevention against breast cancer is warranted. Until these results are replicated, fish oil should not be promoted for reduction of breast cancer risk.