The development of human digital Meissner's and Pacinian corpuscles
The development of human digital Meissner's and Pacinian corpuscles
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DOI：
10.1016/j.aanat.2018.05.001
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发表时间：
2018-01-01
影响因子：
2.2
通讯作者：
Vega, J. A.
中科院分区：
文献类型：
--
作者：
Feito, J.;Garcia-Suarez, O.;Vega, J. A.
迈斯纳小体和帕西尼小体是负责不同触摸方式的皮肤机械感受器。人们对人类这些感觉结构的发育知之甚少，特别是关于获得与其完全功能成熟度相关的典型免疫组织化学特征。在这里，我们使用一组抗体（专门标记主要的红细胞成分：轴突、施万相关细胞和神经内膜-神经周相关细胞）来研究代表性样本中数字迈斯纳氏小体和帕西尼氏小体的发育，样本涵盖从估计孕龄（wega）到成年的 11 周。帕西尼小体的发育从 13 wega 开始，在生命 4 个月时完成，尽管其基本结构和免疫组织化学特征在 36 wega 时达到。在发育过程中，在轴突周围，由 5100 个正向雪旺相关过程组成的复杂网络逐渐压缩以形成内核，而周围的间充质则组织起来并形成外核和胶囊。迈斯纳氏小体在 22 岁时开始发育，并在出生后 8 个月时完成其典型的形态和免疫组织化学特征。在迈斯纳氏小体的发育过程中，轴突与表皮建立了复杂的关系，并逐渐被雪旺样细胞覆盖，直到它们在出生后晚期完成成熟的排列。目前的结果证明迈斯纳小体和帕西尼小体的异步发育，并表明形态学和免疫组织化学成熟之间不存在完全相关性。讨论了当前结果与发育中人类触摸引起的皮层活动的相关性。 (C) 2018 爱思唯尔有限公司。版权所有。
Meissner's and Pacinian corpuscles are cutaneous mechanoreceptors responsible for different modalities of touch. The development of these sensory formations in humans is poorly known, especially regarding the acquisition of the typical immunohistochemical profile related to their full functional maturity. Here we used a panel of antibodies (to specifically label the main corpuscular components: axon, Schwann-related cells and endoneurial-perineurial-related cells) to investigate the development of digital Meissner's and Pacinian corpuscles in a representative sample covering from 11 weeks of estimated gestational age (wega) to adulthood. Development of Pacinian corpuscles starts at 13 wega, and it is completed at 4 months of life, although their basic structure and immunohistochemical characteristics are reached at 36 wega. During development, around the axon, a complex network of 5100 positive Schwann-related processes is progressively compacted to form the inner core, while the surrounding mesenchyme is organized and forms the outer core and the capsule. Meissner's corpuscles start to develop at 22 wega and complete their typical morphology and immunohistochemical profile at 8 months of life. In developing Meissner's corpuscles, the axons establish complex relationships with the epidermis and are progressively covered by Schwann-like cells until they complete the mature arrangement late in postnatal life. The present results demonstrate an asynchronous development of the Meissner's and Pacini's corpuscles and show that there is not a total correlation between morphological and immunohistochemical maturation. The correlation of the present results with touch-induced cortical activity in developing humans is discussed. (C) 2018 Elsevier GmbH. All rights reserved.