Progress and developments in the turbo Grignard reagent i-PrMgCl•LiCl: a ten-year journey
Progress and developments in the turbo Grignard reagent i-PrMgCl•LiCl: a ten-year journey
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DOI：
10.1039/c4cc10194d
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Shi, Lei
中科院分区：
文献类型：
--
作者：
Bao, Robert Li-Yuan;Zhao, Rong;Shi, Lei
过去十年来，i-PrMgCl中心点LiCl的有效性不断被多个研究小组强调。其增强的亲核性为高功能化格氏试剂、其他有用的双金属（碱金属）试剂和温和反应条件下的亲核烷基化产物带来了繁荣。本专题文章以多学科的思路对i-PrMgCl中心点LiCl进行了全面、系统、深入的综述。它涉及 i-PrMgCl 中心点 LiCl 的结构和动力学观点以及其独特的反应性和选择性，对前者的了解有助于合理化后者的趋势。
Over the past decade, the effectiveness of i-PrMgCl center dot LiCl has been constantly highlighted by a number of research groups. Its enhanced nucleophilicity brings prosperity to highly functionalized Grignard reagents, other useful bimetallic (alkali-metal) agents and nucleophilic alkylation products under mild reaction conditions. In this feature article, a comprehensive, systematical and in-depth overview of i-PrMgCl center dot LiCl is provided in a multidisciplinary idea. It involves the structural and kinetic perspectives of i-PrMgCl center dot LiCl as well as its unique reactivity and selectivity, with knowledge of the former helping to rationalize trends of the later.