Effects of bepridil on regional and global myocardial ischemia/reperfusion-induced injury.
Effects of bepridil on regional and global myocardial ischemia/reperfusion-induced injury.
复制标题
贝普地尔对局部和整体心肌缺血/再灌注损伤的影响。
DOI：
10.1159/000138086
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发表时间：
1985
期刊：
影响因子：
3.1
通讯作者：
Lucchesi,BR
中科院分区：
文献类型：
--
作者：
Jackson,CV;Mitsos,SE;Simpson,PJ;Driscoll,EM;Lucchesi,BR
在犬局部缺血模型和猫全脑缺血模型中评估钙离子进入阻滞剂苄普地尔保护心肌免受缺血性损伤的有效性。麻醉开胸犬左回旋支冠状动脉闭塞90分钟，再灌注24小时后，苄普地尔给药（5 mg/kg或15 mg/kg/24 h静脉注射）未减少最终梗死面积。苄普地尔（5毫克/公斤静脉注射给献血猫）没有提供任何保护的分离的血液灌注猫心脏从90分钟的常温全球缺血和60分钟的再灌注。用苄普地尔处理灌注的猫心脏不能防止组织钙的积累或组织钾和ATP的损失。然而，苄普地尔显著降低了犬模型中用于评估最终梗死面积的再灌注快速性心律失常，并防止了猫离体心脏的再灌注诱导的室颤。这些结果表明，钙进入阻滞剂苄普地尔，如在所用模型中评估的，不能保护心肌免受缺血再灌注损伤。然而，它确实可以预防再灌注诱导的快速性心律失常和室颤。
The effectiveness of the calcium entry blocker bepridil in protecting the myocardium from ischemic injury, was assessed in a canine model of regional ischemia and in a feline model of global ischemia. Bepridil administration (5 mg/kg or 15 mg/kg/24 h intravenously) did not reduce ultimate infarct size as assessed in anesthetized, open-chest dogs subjected to 90 min of occlusion of the left circumflex coronary artery and 24 h of reperfusion. Bepridil (5 mg/kg administered intravenously to a blood donor cat) did not provide any protection of the isolated blood-perfused cat heart from 90 min of normothermic global ischemia and 60 min of reperfusion. Treatment of the perfused cat heart with bepridil did not prevent tissue accumulation of calcium or loss of tissue potassium and ATP. Bepridil, however, significantly reduced reperfusion tachyarrhythmias in the dog model for assessing ultimate infarct size and prevented reperfusion-induced ventricular fibrillation of the cat isolated heart. These results indicate that the calcium entry blocker, bepridil, as assessed in the models employed, does not protect the myocardium from ischemic reperfusion injury. However, it does prevent reperfusion-induced tachyarrhythmias and ventricular fibrillation.