Impaired cognitive reappraisal in panic disorder revealed by the late positive potential
Impaired cognitive reappraisal in panic disorder revealed by the late positive potential
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DOI：
10.1097/wnr.0000000000000504
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发表时间：
2016-01
期刊：
影响因子：
1.7
通讯作者：
Bing-Wei Zhang;Jing Xu;Yi Chang;He Wang;H. Yao;Di Tang
中科院分区：
文献类型：
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作者：
Bing-Wei Zhang;Jing Xu;Yi Chang;He Wang;H. Yao;Di Tang
根据惊恐障碍(PD)的认知模型，恐慌症发作是由对身体感觉的灾难性错误评估引发和维持的。临床上，帕金森病与认知情绪调节策略受损有关，涉及认知再评价。为了探讨帕金森病患者认知再评价的神经相关性和时程，本研究记录了帕金森病患者和人口统计学上匹配的对照组在三种情况下的事件相关电位：(A)中性图片前有中性描述，(B)不愉快图片之前有负面描述，(C)不愉快图片之前有中性描述。晚正电位是一种对认知变化策略敏感的事件相关电位成分，可作为认知再评价的指标。与之前的结果一致的是，与控制组中先有中性描述的令人不快的图片相比，先有负面描述的令人不快的图片降低了效价等级，提高了唤醒等级，增加了LPP幅度。相反，在PD组中，没有观察到描述条件对价级的可靠影响。患者表现出与对照组参与者不同的反应模式，在1000-2000毫秒的时间窗口中，当不愉快的图片之前有中性描述时，比不愉快的图片之前有负面描述时，患者具有更高的唤醒评级和更大的LPP。本研究提示帕金森病患者情绪调节功能受损。这些发现描述了帕金森病患者异常认知重新评估的第一个电生理学相关性。
According to the cognitive model of panic disorder (PD), panic attacks are triggered and maintained by catastrophic misappraisals of bodily sensations. Clinically, PD is associated with impaired cognitive emotion regulation strategies involving cognitive reappraisal. To investigate the neural correlates and time course of cognitive reappraisal in patients with PD, event-related potentials were recorded from patients with PD and demographically matched control group during passive viewing of affective images under three conditions: (a) neutral pictures preceded by neutral descriptions, (b) unpleasant pictures preceded by negative descriptions, and (c) unpleasant pictures preceded by neutral descriptions. The late positive potential (LPP), an event-related potential component sensitive to cognitive change strategies, was examined as an index of cognitive reappraisal. Consistent with previous results, the unpleasant pictures preceded by negative descriptions had decreased valence ratings, increased arousal ratings, and increased LPP amplitudes compared with the unpleasant pictures preceded by neutral descriptions in the control group. In contrast, no reliable effect of description condition was observed for valence ratings in the PD group. The patients demonstrated differing response patterns from the control participants, with higher arousal ratings and larger LPPs during the 1000–2000 ms window when unpleasant pictures were preceded by a neutral description than when unpleasant pictures were preceded by a negative description. The present study suggests that emotion regulation is impaired in patients with PD. These findings describe the first electrophysiological correlates of abnormal cognitive reappraisal in patients with PD.