Concurrent advanced HIV disease and viral load suppression in a high-burden setting: Findings from the 2015-6 ZIMPHIA survey
Concurrent advanced HIV disease and viral load suppression in a high-burden setting: Findings from the 2015-6 ZIMPHIA survey
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DOI：
10.1371/journal.pone.0230205
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发表时间：
2020-06-25
期刊：
影响因子：
3.7
通讯作者：
Apollo, T.
中科院分区：
文献类型：
--
作者：
Balachandra, S.;Rogers, J. H.;Apollo, T.
背景：随着津巴布韦开始控制艾滋病毒的流行，现在的项目优先考虑病毒载量而不是CD4监测，这使得很难识别患有晚期疾病的艾滋病毒感染者。我们提出了一项横断面ZIMPHIA数据分析，突出了PLHIV伴AD和并发病毒载量抑制（VLS）。方法ZIMPHIA采集22,501名自愿成人（15岁及以上）血液标本进行HIV检测；3466例PLHIV有CD4和VL检测结果。家庭艾滋病毒检测使用国家串行算法，检测呈阳性的人随后接受护理点CD4计数和随后的VL检测。我们采用logistic回归分析探讨并发AD和VLS的相关因素(
Background As Zimbabwe approaches epidemic control of HIV, programs now prioritize viral load over CD4 monitoring, making it difficult to identify persons living with HIV (PLHIV) suffering from advanced disease (AD). We present an analysis of cross-sectional ZIMPHIA data, highlighting PLHIV with AD and concurrent viral load suppression (VLS). Methods ZIMPHIA collected blood specimens for HIV testing from 22,501 consenting adults (ages 15 years and older); 3,466 PLHIV had CD4 and VL results. Household HIV testing used the national serial algorithm, and those testing positive then received point-of-care CD4 enumeration with subsequent VL testing. We used logistic regression analysis to explore factors associated with concurrent AD and VLS (