Leukoencephalopathy following treatment with carmofur: a case report and review of the Japanese literature.
Leukoencephalopathy following treatment with carmofur: a case report and review of the Japanese literature.
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卡莫氟治疗后白质脑病：病例报告和日本文献综述。
DOI：
10.1111/j.1447-0756.1989.tb00171.x
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发表时间：
2010
影响因子：
1.6
通讯作者：
Y. Masui
中科院分区：
文献类型：
--
作者：
T. Yamada;S. Okamura;T. Okazaki;T. Ushiroyama;Y. Yanagawa;M. Ueki;O. Sugimoto;H. Yamazaki;M. Sugino;Y. Masui
一名53岁的女性于1986年9月因FIGO Ia期卵巢癌手术后接受了5个疗程的CAP治疗。1987年4月，她开始口服卡莫氟400毫克/天的辅助化疗。 6月初，她出现眩晕、构音障碍，入院治疗。 CT 扫描显示两侧侧脑室附近有低密度区域，脑电图显示异常慢波。停药后病情逐渐好转，并于1987年10月出院。日本已有24例因卡莫氟导致白质脑病的报道，但其病理生理机制尚不清楚。由于女性比男性更常见，因此妇科患者的发病率可能会增加。因此，我们必须留意接受卡莫氟辅助化疗的患者的中枢神经系统体征和症状。
A 53-year-old woman was treated with 5 courses of CAP treatment following operation for FIGO Stage Ia cancer of the ovary in September 1986. And in April 1987, she started an oral adjuvant chemotherapy with 400 mg/day of carmofur. In early June, she developed vertigo and dysarthia and was hospitalized. A CT scan showed low-density areas adjacent to both lateral ventricles, and an EEG revealed abnormally slow waves. She improved gradually after carmofur was discontinued and left the hospital in October 1987. There have been 24 reported cases of leukoencephalopathy because of carmofur in Japan, but the pathophysiological mechanism involved is not known. Since it is more common in women than in men, its incidence will probably increase in gynecological patients. Therefore, we must be on the lookout for central nervous system signs and symptoms in patients receiving adjuvant chemotherapy with carmofur.