Evaluation of 2-Deoxy-2-[18F]Fluoro-D-glucose- and 3′-Deoxy-3′-[18F]Fluorothymidine-Positron Emission Tomography as Biomarkers of Therapy Response in Platinum-Resistant Ovarian Cancer
Evaluation of 2-Deoxy-2-[18F]Fluoro-D-glucose- and 3′-Deoxy-3′-[18F]Fluorothymidine-Positron Emission Tomography as Biomarkers of Therapy Response in Platinum-Resistant Ovarian Cancer
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DOI：
10.1007/s11307-012-0554-2
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发表时间：
2012-12-01
影响因子：
3.1
通讯作者：
Aboagye, Eric O.
中科院分区：
文献类型：
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作者：
Perumal, Meg;Stronach, Euan A.;Aboagye, Eric O.
目的：我们评估了2-脱氧-2-[F-18]氟-D-葡萄糖是否（[F-18]FDG）和3 '-脱氧-3'-[F-18]氟胸苷（[F-18]FLT）正电子发射断层扫描（PET）可用作卵巢癌铂再敏感的成像生物标志物。来自同一患者的成对的铂敏感性和铂耐药性卵巢癌细胞PEO 1和PEO 4作为肿瘤异种移植物在裸鼠中生长，结果：AKT抑制剂API-2使耐铂的PEO 4肿瘤对顺铂重新敏感，导致Ki 67标记指数显著降低（p
Purpose: We evaluated whether 2-deoxy-2-[F-18]fluoro-D-glucose ([F-18]FDG) and 3'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT) positron emission tomography (PET) could be used as imaging biomarkers of platinum resensitization in ovarian cancer.Procedures: Paired platinum-sensitive and platinum-resistant ovarian cancer cells from the same patient, PEO1 and PEO4, grown as tumor xenografts in nude mice, were assessed by PET.Results: The AKT inhibitor, API-2, resensitized platinum-resistant PEO4 tumors to cisplatin, leading to a markedly lower Ki67 labeling index (p