Cutting Edge: Granulocyte-Macrophage Colony-Stimulating Factor Is the Major CD8+ T Cell-Derived Licensing Factor for Dendritic Cell Activation
Cutting Edge: Granulocyte-Macrophage Colony-Stimulating Factor Is the Major CD8+ T Cell-Derived Licensing Factor for Dendritic Cell Activation
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DOI：
10.4049/jimmunol.0903873
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发表时间：
2010-05-01
影响因子：
4.4
通讯作者：
Ruedl, Christiane
中科院分区：
文献类型：
--
作者：
Min, Lin;Isa, Siti Aminah Bte Mohammad;Ruedl, Christiane
在启动过程中，CD8(+) T淋巴细胞可以通过分泌许可因子以不依赖cd40的方式诱导树突状细胞（dc）的稳健成熟。在这项研究中，我们分离了这个迄今为止难以捉摸的许可因子，并将其识别为GM-CSF。这为一个在DC开发和招聘中具有众所周知的辅助作用的老因素提供了新的面孔。在体外纯化的dc中，通过GM-CSFR的信号传导比任何已测试的TLR激动剂更有效地上调了共刺激分子的表达，并在刺激CD8(+) T细胞增殖方面提供了一个正反馈回路。结合多种微生物刺激，GM-CSF支持形成有效的“效应”dc，能够分泌多种促炎细胞因子，在免疫应答过程中引导T细胞分化。中华免疫学杂志，2010,18(4):625- 629。
During priming, CD8(+) T lymphocytes can induce robust maturation of dendritic cells (DCs) in a CD40-independent manner by secreting licensing factor(s). In this study, we isolate this so-far elusive licensing factor and identify it, surprisingly, as GM-CSF. This provides a new face for an old factor with a well-known supporting role in DC development and recruitment. Signaling through the GM-CSFR in ex vivo-purified DCs upregulated the expression of costimulatory molecules more efficiently than did any tested TLR agonist and provided a positive feedback loop in the stimulation of CD8(+) T cell proliferation. Combined with a variety of microbial stimuli, GM-CSF supports the formation of potent "effector" DCs capable of secreting a variety of proinflammatory cytokines that guide the differentiation of T cells during the immune response. The Journal of Immunology, 2010, 184: 4625-4629.