Hepatocellular carcinoma induces body mass loss in parallel with osmolyte and water retention in rats
Hepatocellular carcinoma induces body mass loss in parallel with osmolyte and water retention in rats
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肝细胞癌引起大鼠体重损失，同时导致渗透压和水潴留
DOI：
10.1016/j.lfs.2021.120192
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发表时间：
2022
期刊：
影响因子：
6.1
通讯作者：
Nishiyama Akira
中科院分区：
文献类型：
--
作者：
Kidoguchi Satoshi;Kitada Kento;Nakajima Kazuki;Nakano Daisuke;Ohsaki Hiroyuki;Kittikulsuth Wararat;Kobara Hideki;Masaki Tsutomu;Yokoo Takashi;Takahashi Kazuo;Titze Jens;Nishiyama Akira
患有心血管疾病的癌症幸存者人数正在增加。然而，癌症对体液调节的影响仍有待澄清。在这项研究中，我们评估了身体渗透压和水的不平衡，大鼠与hepatocellularcarcinoma.Main methodsWistar大鼠给予二乙基亚硝胺，致癌药物，建立肝癌。我们分析了组织渗透压和水含量，以及它们与醛固酮分泌的关系。Key findingsHepatocellular carcinoma大鼠的体重和全身钠，钾和水的量显着减少。然而，这些大鼠每组织干重的相对组织钠、钾和水含量显著增加。此外，这些变化在肝细胞癌大鼠的钠和水平衡显着相关的增加24小时尿醛固酮排泄。在饮用水中补充0.25%的盐可以改善肝细胞癌大鼠的体重减轻，并伴有钠和水潴留，而这一点可以通过盐皮质激素受体拮抗剂螺内酯治疗来抑制。此外，尿素驱动的水保护系统被激活，在hepatocellular carcinoma rats.SignificanceThese研究结果表明，肝细胞癌诱导体重减轻与激活的水保护系统，包括醛固酮分泌和尿素积累，以保持渗透压和水。组织水平的渗透压和水潴留可能是肝衰竭大鼠腹水和水肿形成的原因之一。
AimsThe number of cancer survivors with cardiovascular disease is increasing. However, the effect of cancer on body fluid regulation remains to be clarified. In this study, we evaluated body osmolyte and water imbalance in rats with hepatocellular carcinoma.Main methodsWistar rats were administered diethylnitrosamine, a carcinogenic drug, to establish liver cancer. We analyzed tissue osmolyte and water content, and their associations with aldosterone secretion.Key findingsHepatocellular carcinoma rats had significantly reduced body mass and the amount of total body sodium, potassium, and water. However, these rats had significantly increased relative tissue sodium, potassium, and water content per tissue dry weight. Furthermore, these changes in sodium and water balance in hepatocellular carcinoma rats were significantly associated with increased 24-h urinary aldosterone excretion. Supplementation with 0.25% salt in drinking water improved body weight reduction associated with sodium and water retention in hepatocellular carcinoma rats, which was suppressed by treatment with spironolactone, a mineralocorticoid receptor antagonist. Additionally, the urea-driven water conservation system was activated in hepatocellular carcinoma rats.SignificanceThese findings suggest that hepatocellular carcinoma induces body mass loss in parallel with activation of the water conservation system including aldosterone secretion and urea accumulation to retain osmolyte and water. The osmolyte and water retention at the tissue level may be a causative factor for ascites and edema formation in liver failure rats.