Management of influenza virus infections with neuraminidase inhibitors: detection, incidence, and implications of drug resistance.
Management of influenza virus infections with neuraminidase inhibitors: detection, incidence, and implications of drug resistance.
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DOI：
10.2165/00151829-200504020-00004
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发表时间：
2005-01-01
期刊：
影响因子：
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通讯作者：
McKimm-Breschkin, Jennifer L
中科院分区：
文献类型：
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作者：
McKimm-Breschkin, Jennifer L
虽然流感疫苗接种仍然是预防流感的主要方法，但由于疫苗与流行毒株之间的匹配性差以及老年患者的反应差，因此其疗效可能受到限制。因此，抗病毒治疗在流感管理中具有重要作用。虽然金刚烷胺和金刚乙胺已在一些国家用于治疗流感多年，但它们仅对甲型流感病毒有效，它们可能具有神经和胃肠道不良反应，并且耐药病毒迅速产生。神经氨酸酶抑制剂是一种新型药物，对所有流感病毒株都具有有效和特异性的抑制剂，并且它们具有最小的副作用。最大的好处是在那些病人表现出
Although influenza vaccination remains the primary method for the prevention of influenza, efficacy may be limited by a poor match between the vaccine and circulating strains and the poor response of elderly patients. Hence, there is an important role for antiviral therapy in the management of influenza. While amantadine and rimantadine have been available for the treatment of influenza in some countries for several years, they are only effective against influenza A viruses, they can have neurological and gastrointestinal adverse effects, and resistant virus is rapidly generated. Neuraminidase inhibitors, a new class of drug, are potent and specific inhibitors of all strains of influenza virus, and they have minimal adverse effects. The greatest benefit is seen in those patients presenting