THE DEVELOPMENTAL CONSEQUENCES OF LOW TO MODERATE PRENATAL AND POSTNATAL LEAD-EXPOSURE - INTELLECTUAL ATTAINMENT IN THE CINCINNATI LEAD STUDY COHORT FOLLOWING SCHOOL ENTRY
THE DEVELOPMENTAL CONSEQUENCES OF LOW TO MODERATE PRENATAL AND POSTNATAL LEAD-EXPOSURE - INTELLECTUAL ATTAINMENT IN THE CINCINNATI LEAD STUDY COHORT FOLLOWING SCHOOL ENTRY
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DOI：
10.1016/0892-0362(93)90043-n
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发表时间：
1993-01-01
影响因子：
2.9
通讯作者：
BORNSCHEIN, RL
中科院分区：
文献类型：
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作者：
DIETRICH, KN;BERGER, OG;BORNSCHEIN, RL
在辛辛那提领先研究队列的进一步后续研究中，253名儿童在大约6.5岁时接受了韦克斯勒儿童智力量表(WISC-R)的测试。出生后血铅浓度与总分(FSIQ)和操作智商(PIQ)呈负相关。在对母亲智商等发育辅助因素进行统计调整和对家庭环境中的照料质量进行评估后，出生后血铅浓度和PIQ之间仍然存在统计上的显著关系。进一步的统计分析表明，与平均血铅浓度低于或等于10微克/分升的儿童相比，一生平均血铅浓度超过20微克/分升的儿童与PIQ下降约7分。这些结果从它们与其他类似研究的一致性以及它们与先前关于该队列的报告的内部一致性方面进行了讨论。这项调查的结果支持美国最近为减少儿童接触环境铅而采取的举措。
In a further follow-up study of the Cincinnati Lead Study Cohort, 253 children were administered the Wechsler Intelligence Scale for Children-Revised (WISC-R) at approximately 6.5 years of age. Postnatal blood lead concentrations were inversely associated with Full-Scale (FSIQ) and Performance IQ (PIQ). Following statistical adjustment for developmental co-factors such as maternal IQ and an assessment of the quality of caretaking in the home environment, a statistically significant relationship remained between postnatal blood lead concentrations and PIQ. Further statistical analyses suggested that averaged lifetime blood lead concentrations in excess of 20 mug/dL were associated with deficits in PIQ on the order of approximately 7 points when compared to children with mean concentrations less or equal to 10 mug/dL. These results are discussed in terms of their consistency with other similar studies as well as their internal consistency with earlier reports on this cohort. The findings of this investigation support recent initiatives in the United States to reduce the exposure of children to environmental lead.