Estimation of Trends in Serum and RBC Folate in the U.S. Population from Pre- to Postfortification Using Assay-Adjusted Data from the NHANES 1988-2010
Estimation of Trends in Serum and RBC Folate in the U.S. Population from Pre- to Postfortification Using Assay-Adjusted Data from the NHANES 1988-2010
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DOI：
10.3945/jn.111.156919
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发表时间：
2012-05-01
影响因子：
4.2
通讯作者：
Johnson, Clifford L.
中科院分区：
文献类型：
--
作者：
Pfeiffer, Christine M.;Hughes, Jeffery P.;Johnson, Clifford L.
NHANES通过测量血清和RBC叶酸浓度，监测了从强化前（1988-1994）到强化后（1999-2010）美国人群的叶酸水平。1988年至2006年使用Bio-Rad放射性测定法（BR），2007年至2010年使用微生物测定法（MBA）。MBA产生的浓度高于BR，被认为更准确。因此，为了弥合测定差异并检查叶酸随时间的变化趋势，我们调整了BR结果，使其与MBA结果相当。强化后，分析校正的血清和RBC叶酸浓度分别为强化前浓度的2.5倍和1.5倍，并在1999-2010年期间显示出显著的线性趋势（P < 0.001），浓度略低。低血糖的发生率（
The NHANES has monitored folate status of the U.S. population from prefortification (1988-1994) to postfortification (1999-2010) by measuring serum and RBC folate concentrations. The Bio-Rad radioassay (BR) was used from 1988 to 2006, and the microbiologic assay (MBA) was used from 2007 to 2010. The MBA produces higher concentrations than the BR and is considered to be more accurate. Thus, to bridge assay differences and to examine folate trends over time, we adjusted the BR results to be comparable to the MBA results. Postfortification, assay-adjusted serum and RBC folate concentrations were 2.5 times and 1.5 times prefortification concentrations, respectively, and showed a significant linear trend (P < 0.001) to slightly lower concentrations during 1999-2010. The postfortification prevalence of low serum (