Verbal memory performance of patients with a first depressive episode and patients with unipolar and bipolar recurrent depression
Verbal memory performance of patients with a first depressive episode and patients with unipolar and bipolar recurrent depression
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DOI：
10.1016/j.jpsychires.2003.08.002
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发表时间：
2004-03-01
影响因子：
4.8
通讯作者：
Allilaire, JF
中科院分区：
文献类型：
--
作者：
Fossati, P;Harvey, PO;Allilaire, JF
抑郁症通常与间歇性记忆障碍有关。与记忆损害相关的抑郁症的主要临床特征没有明确的定义。这项研究的主要目的是评估诊断亚型和抑郁发作次数对急性单相(UP)和双相(BP)抑郁症患者记忆表现的影响。对23例首次抑郁发作(FE)患者、28例符合DSM-IV诊断标准的复发性抑郁症(UR)患者和18例BP复发性抑郁症患者与88例健康受试者进行言语情景记忆任务的比较。与正常对照组相比，首次抑郁发作的患者没有表现出言语记忆障碍。与FE患者不同，UR和BP患者表现出言语记忆缺陷，自由回忆受损，线索回忆和再认正常。UR和BP患者的记忆缺陷出现在第一次自由回忆试验中。在这项任务的三次试验中，抑郁症患者的记忆表现改善的速度与正常对照组相同。我们的结果表明，抑郁发作的次数对急性抑郁患者的言语记忆表现有负面影响。重复抑郁发作的效果不受抑郁亚型的调节，可能反映了对抑郁与不断增加的前额叶功能障碍相关的认知影响的敏感化。(C)2003爱思唯尔有限公司。保留所有权利。
Depression is usually associated with episodic memory impairment. The main clinical features of depression associated with that memory impairment are not clearly defined. The main goal of that study was to assess the role of the diagnostic subtypes and the number of depressive episodes on the memory performance of acute unipolar (UP) and bipolar (BP) depressed patients. Twenty-three patients with a first major depressive episode (FE), 28 patients meeting DSM-IV criteria for UP recurrent depression (UR) and 18 BP patients with recurrent depression were compared with 88 healthy subjects on a verbal episodic memory task. Patients suffering from a first depressive episode did not show verbal memory impairment as compared to normal controls. Unlike FE patients, UR and BP patients exhibited verbal memory deficits with impaired free recall and normal cued recall and recognition. The memory deficits of the UR and BP patients was present in the first free recall trial. Depressed patients improved their memory performance across the three trials of the task at the same rate than normal controls. Our results suggest that the number of depressive episodes has a negative influence on verbal memory performance of acute depressed patients. The effects of the repetition of the depressive episodes are not modulated by the subtypes of depression and may reflect sensitization to the cognitive impact of depression associated with increasing prefrontal dysfunction. (C) 2003 Elsevier Ltd. All rights reserved.