Dopamine is a double-edged sword: dopaminergic modulation enhances memory retrieval performance but impairs metacognition
Dopamine is a double-edged sword: dopaminergic modulation enhances memory retrieval performance but impairs metacognition
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DOI：
10.1038/s41386-018-0246-y
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发表时间：
2019-02-01
影响因子：
7.6
通讯作者：
Sommer, Tobias
中科院分区：
文献类型：
--
作者：
Clos, Mareike;Bunzeck, Nico;Sommer, Tobias
虽然记忆编码和巩固过程长期以来一直与多巴胺能信号联系在一起，但多巴胺在情景记忆提取中的作用大多仍未被探索。基于前人对记忆提取过程中纹状体活动的观察，我们利用药理学功能磁共振成像技术研究了多巴胺对健康人提取成绩和元认知记忆信心的影响。在提取阶段，通过D2拮抗剂氟哌啶醇的多巴胺能调制显著提高了对先前学习的图片的识别准确率，并与提取过程中黑质/腹侧被盖区、蓝斑、海马体和杏仁核的活动增加有关。相比之下，在氟哌啶醇作用下，对新决定的信心受到纹状体在信心水平和额纹状体网络反应范围受限时纹状体活动的非系统性增加的影响。这些发现为记忆提取和元认知的潜在机制提供了新的见解，并为多巴胺相关疾病中记忆问题的存在和记忆障碍的治疗提供了更广阔的视角。
While memory encoding and consolidation processes have been linked with dopaminergic signaling for a long time, the role of dopamine in episodic memory retrieval remained mostly unexplored. Based on previous observations of striatal activity during memory retrieval, we used pharmacological functional magnetic resonance imaging to investigate the effects of dopamine on retrieval performance and metacognitive memory confidence in healthy humans. Dopaminergic modulation by the D2 antagonist haloperidol administered acutely during the retrieval phase improved recognition accuracy of previously learned pictures significantly and was associated with increased activity in the substantia nigra/ventral tegmental area, locus coeruleus, hippocampus, and amygdala during retrieval. In contrast, confidence for new decisions was impaired by unsystematically increased activity of the striatum across confidence levels and restricted range of responsiveness in frontostriatal networks under haloperidol. These findings offer new insights into the mechanisms underlying memory retrieval and metacognition and provide a broader perspective on the presence of memory problems in dopamine-related diseases and the treatment of memory disorders.