SEQUENCE OF A NOVEL CARBONIC ANHYDRASE-RELATED POLYPEPTIDE AND ITS EXCLUSIVE PRESENCE IN PURKINJE-CELLS
SEQUENCE OF A NOVEL CARBONIC ANHYDRASE-RELATED POLYPEPTIDE AND ITS EXCLUSIVE PRESENCE IN PURKINJE-CELLS
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DOI：
10.1016/0014-5793(90)80390-5
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发表时间：
1990-10-01
期刊：
影响因子：
3.5
通讯作者：
KATO, K
中科院分区：
文献类型：
--
作者：
KATO, K
我分离了一个小鼠cDNA克隆，编码一种新的多肽，它与碳酸酐酶具有很强的同源性。与其他碳酸酐酶不同，它有一个额外的N-末端结构域，带有谷氨酸延伸和精氨酸取代结合锌离子的三个组氨酸残基之一。在中枢神经系统中，已知碳酸酐酶仅在神经胶质细胞中表达，但该基因在神经元中表达，但仅在浦肯野细胞中表达。
I isolated a mouse cDNA clone encoding a novel polypeptide which has strong homology with carbonic anhydrase. Unlike the other carbonic anhydrases, it has an additional N‐terminal domain with a glutamic acid stretch and an arginine substitutes one of the three histidine residues which bind zinc ion. In the central nervous system, carbonic anhydrase is known to be expressed only in glia cells, but this gene is expressed in neuron, but only in Purkinje cells.