Tactile stimulation of the hand causes bilateral cortical activation: a functional magnetic resonance study in humans
Tactile stimulation of the hand causes bilateral cortical activation: a functional magnetic resonance study in humans
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DOI：
10.1016/s0304-3940(99)00508-x
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发表时间：
1999-08-13
影响因子：
2.5
通讯作者：
Brismar, T
中科院分区：
文献类型：
--
作者：
Hansson, T;Brismar, T
本研究的目的是评估使用自然的触觉刺激的无毛皮肤的手指的皮层感觉表征的体感。多层回声平面成像技术被用来调查血氧水平依赖（BOLD）的信号变化作为皮质激活的措施。手指II-III和手指IV-V的无毛皮肤的重复感觉刺激导致对侧半球中央沟附近的限制区域中的多灶信号增加，手指II-III和手指IV-V的激活区域之间有相当大的重叠。此外，在所有受试者中，触觉刺激导致中央沟附近的同侧信号增加，这是对侧效应的15-22%。在对侧半球，刺激手指II-III比手指IV-V引起显著（P < 0.05）更多的激活体素，对于双手和同侧半球的左手。这些发现表明，在人类的手指自然触觉刺激的同侧激活的初级躯体感觉皮层。(C)1999爱思唯尔科学爱尔兰有限公司版权所有。
The purpose of the present study was to assess the somatotopy of the cortical sensory representation of the fingers using a natural tactile stimulation of the glabrous skin. Multislice echoplanar imaging techniques were utilized to investigate blood oxygen level dependent (BOLD) signal changes as a measure of cortical activation. Repetitive sensory stimulation of the glabrous skin of digit II-III and digit IV-V resulted in a multifocal signal increase in a restricted area near the central sulcus in the contralateral hemisphere with a considerable overlap between the activated areas of digit II-III and digit IV-V. In addition, in all subjects tactile stimulation resulted in ipsilateral signal increase near the central sulcus, which was 15-22% of the contralateral effect. Stimulation of digit II-III caused significantly (P < 0.05) more activated voxels than digit IV-V in the contralateral hemisphere for both hands and for the left hand in the ipsilateral hemisphere. These findings suggest an ipsilateral activation of the primary somatosensory cortex during a natural tactile stimulation of the digits in humans. (C) 1999 Elsevier Science ireland Ltd. All rights reserved.