Levels of Interleukin 27 and Interleukin 35 in the Serum and Vitreous of Patients with Proliferative Diabetic Retinopathy
Levels of Interleukin 27 and Interleukin 35 in the Serum and Vitreous of Patients with Proliferative Diabetic Retinopathy
复制标题
增殖性糖尿病视网膜病变患者血清和玻璃体中白细胞介素 27 和白细胞介素 35 的水平
DOI：
10.1080/09273948.2016.1203959
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发表时间：
2018-01-01
影响因子：
3.3
通讯作者：
Zhang, Xuedong
中科院分区：
文献类型：
--
作者：
Yan, Ai;You, Hui;Zhang, Xuedong
目的：探讨白细胞介素27（IL-27）和白细胞介素35 （IL-35）在糖尿病视网膜病变（DR）中的作用。方法：将糖尿病患者分为糖尿病无视网膜病变（DWR）组、非增殖性糖尿病视网膜病变（NPDR）组和增殖性糖尿病视网膜病变（PDR）组。以特发性黄斑视网膜前膜（IMEM）患者为对照组。采用ELISA法检测血清和玻璃体中IL-27、IL-35水平。结果：PDR患者血清IL-27（中位数240.900 pg/mL，范围42.224 ~ 617.810 pg/mL, p < 0.001）和IL-35（中位数11.875 ng/mL，范围8.640 ~ 19.340 ng/mL, p < 0.001）水平较对照组（中位数2712.310 pg/mL，范围1005.375 ~ 5786.877 pg/mL，中位数25.185 ng/mL，范围22.845 ~ 29.590 ng/mL）显著降低。PDR患者玻璃体中IL-35水平（16.32±3.24 ng/mL）明显低于对照组（24.54±5.86 ng/mL, p < 0.001）。结论：血清和玻璃体中IL-35和IL-27水平可能与PDR的发病机制有关。
ABSTRACT Purpose: To examine the role of interleukin 27(IL-27) and interleukin 35 (IL-35) in diabetic retinopathy (DR). Methods: Patients with diabetes mellitus were divided into three groups: diabetes without retinopathy (DWR), non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR). Patients with idiopathic macular epiretinal membrane (IMEM) were included as a control group. The serum and vitreous levels of IL-27 and IL-35 were measured using ELISA. Results: The serum levels of IL-27 (median 240.900 pg/mL, range 42.224 – 617.810 pg/mL; p < 0.001) and IL-35 (median 11.875 ng/mL, range 8.640 – 19.340 ng/mL; p < 0.001) were significantly decreased in PDR patients compared to controls (median 2712.310 pg/mL, range 1005.375–5786.877 pg/mL and median 25.185 ng/mL, range 22.845 – 29.590 ng/mL, respectively). The vitreous levels of IL-35 were significantly decreased in PDR patients (16.32 ± 3.24 ng/mL) compared to controls (24.54 ± 5.86 ng/mL, p < 0.001). Conclusions: Serum and vitreous levels of IL-35 and serum level of IL-27 may be associated with the pathogenesis of PDR.