p53 and Breast Cancer
p53 and Breast Cancer
复制标题
DOI：
10.1177/106689699600400206
复制
发表时间：
1996-10
影响因子：
1.2
通讯作者：
P. Robbins
中科院分区：
文献类型：
--
作者：
P. Robbins
p53肿瘤抑制基因的失活是人类乳腺癌中最常见的遗传变化之一。在这篇综述中，将讨论p53基因及其蛋白产物的结构和功能，特别是p53的改变，有助于致癌。频率和模式的p53改变在乳腺癌中将被概述，其检测的实验室方法进行了简要总结，并讨论了p53作为预后和预测标记物的潜在用途。
Inactivation of the p53 tumor suppressor gene is one of the commonest genetic changes identified in human breast cancer. In this review, the structure and function of the p53 gene and its protein products will be discussed, with particular reference to p53 alterations that contribute to carcinogenesis. The frequency and pattern of p53 alterations in breast cancer will be outlined, laboratory methods for their detection briefly summarized, and the potential use of p53 as a prognostic and predictive marker discussed.