Expression of IL-25, IL-33, and Thymic Stromal Lymphopoietin in Nasal Polyp Gland Duct Epithelium in Patients With Chronic Rhinosinusitis
Expression of IL-25, IL-33, and Thymic Stromal Lymphopoietin in Nasal Polyp Gland Duct Epithelium in Patients With Chronic Rhinosinusitis
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DOI：
10.1177/1945892419835333
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发表时间：
2019-03
影响因子：
2.6
通讯作者：
Y. Nagata;S. Maruoka;Y. Gon;Kenji Mizumura;H. Kishi;Y. Nomura;Mari Hikichi;S. Hashimoto;Takeshi Oshima
中科院分区：
文献类型：
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作者：
Y. Nagata;S. Maruoka;Y. Gon;Kenji Mizumura;H. Kishi;Y. Nomura;Mari Hikichi;S. Hashimoto;Takeshi Oshima
背景鼻息肉伴发嗜酸性粒细胞性慢性鼻窦炎（ECRS）。鼻粘膜中表达的细胞因子，包括白细胞介素（IL）-25，IL-33和胸腺基质淋巴细胞生成素（TSLP）与息肉的发病有关。我们研究了鼻息肉上皮细胞因子表达在ECRS嗜酸性粒细胞浸润中的作用。方法收集39例鼻手术患者的组织标本。将病例分为3组：对照组（CTR）、非ECRS组（nECRS）和ECRS组，并评估IL-25、IL-33和TSLP表达。结果在鼻息肉组织中，鼻黏膜下及鼻导管周围有大量嗜酸性粒细胞浸润，嗜酸性粒细胞浸润程度与IL-33蛋白表达呈正相关。结论鼻息肉组织中存在与鼻黏膜相似的细胞因子表达和嗜酸性粒细胞浸润，提示鼻息肉组织中存在嗜酸性粒细胞浸润。
Background Nasal polyps accompany eosinophilic chronic rhinosinusitis (ECRS). Cytokines, including interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) expressed in nasal mucosa have been implicated in polyp pathogenesis. We investigated the role of nasal polyp epithelium cytokine expression in eosinophilic infiltration in ECRS. Methods Tissues were collected from 39 patients undergoing nasal surgery. Cases were divided into 3 groups: control (CTR), non-ECRS (nECRS), and ECRS and were evaluated for IL-25, IL-33, and TSLP expression. Results Abundant eosinophilia was observed underneath the nasal mucosa and around the nasal ducts in polyps in ECRS and correlated positively with IL-33 protein expression. Conclusion Cytokine expression in nasal duct cells and eosinophilic infiltration around duct cells similar to those in the nasal mucosa occurred in the nasal epithelium of polyps, suggesting its role in inducing eosinophilic inflammation.