Treatment-induced changes in vocal cord mobility and subsequent local recurrence after organ preservation therapy for laryngeal carcinoma
Treatment-induced changes in vocal cord mobility and subsequent local recurrence after organ preservation therapy for laryngeal carcinoma
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DOI：
10.1002/hed.21813
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发表时间：
2012-06-01
影响因子：
2.9
通讯作者：
Esclamado, Ramon M.
中科院分区：
文献类型：
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作者：
Lee, Walter T.;Yoo, David S.;Esclamado, Ramon M.
背景 随着多学科癌症治疗的发展，有必要制定策略来识别需要早期切除/挽救的患者。一些人认为器官保存治疗后的声带功能可能是一个指标。方法对三级中心声带功能固定或受损的患者进行回顾性审查。对治疗后活动能力改善/正常和未改善的患者的局部复发率进行了检查。结果 69例患者符合纳入标准，其中35例声带固定，34例活动障碍。治疗后，44 名患者声带功能恢复正常，25 名患者未恢复正常，2 年局部控制率分别为 70% 和 77%，p = 0.23。脊髓功能正常/改善的患者 (n = 53) 和脊髓功能保持不变/恶化的患者 (n = 16；p = .81) 之间没有发现局部控制差异。结论 治疗引起的声带活动度变化与局部复发无关。需要其他标准来确定最有可能从器官保存后早期手术切除/抢救中受益的患者。 (c) 2011 Wiley periodicals, Inc. Head Neck，2011
Background As multidisciplinary cancer treatment evolves, strategies to identify patients needing early resection/salvage are necessary. Some have suggested that vocal cord function after organ-preservation treatment may be an indicator. Methods A retrospective review was performed of patients presenting with fixed or impaired vocal cord function at a tertiary center. Local recurrence rates were examined in patients with and without improved/normal mobilization after treatment. Results Sixty-nine patients met the inclusion criteria, with 35 patients having vocal cord fixation and 34 patients with impaired mobility. After treatment, 44 patients had normalization of vocal cord function, while 25 patients did not, with 2-year local control rates of 70% and 77%, p = .23, respectively. No difference in local control was found between patients with normalized/improved cord function (n = 53) and those who remained the same/worsened (n = 16; p = .81). Conclusion Therapy-induced changes in vocal cord mobility did not correlate with local recurrence. Other criteria are needed to identify patients most likely to benefit from early surgical resection/salvage after organ preservation. (c) 2011 Wiley Periodicals, Inc. Head Neck, 2011