Synthesis of Polyhedral Metal-Organic Framework@Mesoporous Silica Hybrid Nanocomposites with Branched Shapes.
Synthesis of Polyhedral Metal-Organic Framework@Mesoporous Silica Hybrid Nanocomposites with Branched Shapes.
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多面体金属-有机骨架@介孔二氧化硅支化杂化纳米复合材料的合成
DOI：
10.1021/acsabm.0c01518
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发表时间：
2021-02
影响因子：
4.7
通讯作者：
Qi Lei;Jimin Guo;Esmeralda Arreguin-Martinez;Jianjun Shi;C. Brinker;Wei Zhu
中科院分区：
文献类型：
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作者：
Qi Lei;Jimin Guo;Esmeralda Arreguin-Martinez;Jianjun Shi;C. Brinker;Wei Zhu
多室多孔纳米材料的结构调控是纳米科学的主要挑战之一。本文利用金属有机骨架（MOF）的多面体效应/特性，提出了一种多用途的方法来构建MOF核、SiO2壳和周期性介孔有机二氧化硅（PMO）分支的MOF-有机二氧化硅杂化支链纳米复合材料。所获得的杂化纳米复合材料的形态、结构和功能可以通过改变MOF核心的颗粒大小、形状或晶体结构来轻松调节。具体来说，与巨噬细胞相比，这些支状多室多孔纳米颗粒在上皮细胞中表现出逃避行为，这可能赋予它们作为免疫治疗载体的巨大潜力。
The structural modulation of multicompartment porous nanomaterials is one of the major challenges of nanoscience. Herein, by utilizing the polyhedral effects/characteristics of metal-organic frameworks (MOFs), we present a versatile approach to construct MOF-organosilica hybrid branched nanocomposites with MOF cores, SiO2 shells, and periodic mesoporous organosilica (PMO) branches. The morphology, structure, and functions of the obtained hybrid nanocomposites can be facilely modulated by varying particle size, shape, or crystalline structures of the MOF cores. Specifically, these branched multicompartment porous nanoparticles exhibit evasion behaviors in epithelial cells compared with macrophage cells, which may endow them great potential as a vehicle for immunotherapy.