Assessment of the primary effect of aging on heart rate variability in humans
Assessment of the primary effect of aging on heart rate variability in humans
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DOI：
10.1007/bf02278016
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发表时间：
2000-06-01
影响因子：
5.8
通讯作者：
Yamamoto, Y
中科院分区：
文献类型：
--
作者：
Fukusaki, C;Kawakubo, K;Yamamoto, Y
心率变异性（HRV）反映了心脏自主控制机制，已知随年龄而变化。然而，这种变化在多大程度上是由衰老本身或正常衰老的生理变化特征介导的，目前尚不清楚。本研究旨在探讨有氧健身，体型或肥胖，血压与年龄相关的HRV变化的关联。静息心率变异性数据记录从373名健康受试者（124名男性，249名女性;年龄范围，16-69岁），并通过粗粒度频谱分析，将总频谱功率分解为谐波和分形分量进行分析。从前者计算低频和高频（LF，0.0-0.15 Hz; HF，> 0.15 Hz）谐波分量，而后者用于计算积分功率（FR）和频谱指数β，进而用于评估HRV的整体复杂性。进行因子分析，以测试是否可能与年龄相关的变化的组成部分的HRV可能会观察到次要通过其他变量影响HRV。HRV的谐波（HF和LF）和分形（FR和β）分量的显著（p < 0.05）年龄相关变化与文献中描述的基本一致。此外，因子分析表明，有一个独特的共同因素，主要解释了年龄，HF和β（p < 0.05）之间的相关性，而没有LF，FR，有氧健身，体型或肥胖和血压的贡献。得出的结论是，在这个基于人群的样本中，HF和β的年龄相关变化，这两者都反映了心率的迷走神经调制，主要是由老化本身介导的，而不是由正常老化的生理变化特征。
Beat-to-beat heart rate variability (HRV), reflecting cardiac autonomic control mechanisms, is known to change with age. However, the degree to which this change is mediated by aging per se or by physiologic changes characteristic of normative aging is still unclear. This study was designed to examine the association of aerobic fitness, body habitus or obesity, and blood pressure with age-related changes in HRV. Resting HRV data was recorded from 373 healthy subjects (124 men, 249 women; age range, 16-69 y) and analyzed by coarse-graining spectral analysis to decompose the total spectral power into its harmonic and fractal components. The low- and high-frequency (LF, 0.0-0.15 Hz; HF, > 0.15 Hz) harmonic components were calculated from the former, whereas the latter was used to calculate the integrated power (FR) and the spectral exponent beta, which were, in turn, used to evaluate the overall complexity of HRV. Factor analysis was performed to test whether potentially age-related changes in the components of HRV might be observed secondarily through other variables affecting HRV. Significant (p < 0.05) age-related changes in the harmonic (HF and LF) and fractal (FR and beta) components of HRV were generally consistent with those described in the literature. In addition, factor analysis showed that there was a unique common factor that primarily explained correlations among age, HF, and beta (p < 0.05) without the contributions from LF, FR, aerobic fitness, body habitus or obesity, and blood pressure. It was concluded that, in this population-based sample, age-related changes in HF and beta, both of which reflect vagal modulation of heart rate, were primarily mediated by aging per se and not by physiologic changes characteristic of normative aging.