INHIBITION OF IMMUNE-RESPONSE BY RAPAMYCIN, A NEW ANTIFUNGAL ANTIBIOTIC
INHIBITION OF IMMUNE-RESPONSE BY RAPAMYCIN, A NEW ANTIFUNGAL ANTIBIOTIC
复制标题
DOI：
10.1139/y77-007
复制
发表时间：
1977-01-01
影响因子：
2.1
通讯作者：
GALET, S
中科院分区：
文献类型：
--
作者：
MARTEL, RR;KLICIUS, J;GALET, S
雷帕霉素是一种新型抗真菌抗生素，可抑制大鼠的免疫反应。它完全阻止了两种实验性免疫病[实验性过敏性脑脊髓炎（EAE）和佐剂性关节炎（AA）]的发展和体液（Ig[免疫球蛋白）E样）抗体的形成。它抑制 EAE 的效力约为环磷酰胺的一半。在 AA 和抗体形成中，雷帕霉素和环磷酰胺的效力大致相同，而甲氨蝶呤的效力更强。雷帕霉素的免疫抑制剂活性似乎与淋巴系统的抑制有关。
Rapamycin, a new antifungal antibiotic, inhibited the immune response in rats. It totally prevented the development of 2 experimental immunopathies [experimental allergic encephalomyelitis (EAE) and adjuvant arthritis (AA)] and the formation of humoral (Ig[immunoglobulin)E-like) antibody. It was about half as potent as cyclophosphamide in inhibiting EAE. In AA and on antibody formation, rapamycin and cyclophosphamide were about equipotent, whereas methotrexate was more potent. The immunosuppressant activity of rapamycin appears to be related to inhibition of the lymphatic system.